A case report of sporadic inclusion body myositis
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 2
Abstract
A retrospective analysis was performed to analyze clinical manifestations, muscle imaging, histopathology, immunopathology, ultrastructure, and myositis antibody spectrum in a patient with sporadic inclusion body myositis (sIBM). The patient, 69-year-old male, presented with progressive weakness in the lower extremity, accompanied by decreased grip strength and mild difficulty in swallowing. Serum creatine kinase levels were mildly elevated; electromyography showed myogenic damage; thigh muscle MRI revealed fatty infiltration in the vastus lateralis, vastus medialis and vastus intermedius, with relatively preserved rectus femoris, semimembranosus and semitendinosus muscles. Muscle histopathology demonstrated moderate inflammatory myopathy with rimmed vacuoles and the intracellular deposition of p62 (Sequestosome 1) and TDP-43 (TAR DNA binding protein-43); Electron microscopy revealed a moderate number of turbinate-shaped myeloid bodies; Myositis antibody spectrum demonstrated positivity for anti-cN1A (cytoplasmic 5'-nucleotidase 1A) antibodies. sIBM demonstrated unique features in the age of onset and patterns of muscle group involvement. However, early clinical manifestations lacked specificity, making the diagnosis challenging. Molecular biomarkers played a crucial role in aiding accurate diagnosis and facilitating mechanistic study.
Authors and Affiliations
Xiaodan LIN, Long CHEN, Fuze ZHENG, Ying ZHENG, Minghui ZENG, Feng LIN, Minting LIN, Ning WANG, Zhiqiang WANG
Keywords
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- EP ID EP750420
- DOI 10.3969/j.issn.1002-0152.2024.02.008
- Views 49
- Downloads 0
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