Combination of olfactory features with cognitive testing in diagnosis of mild cognitive impairment
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 2
Abstract
[Objective] To explore the value of olfactory features combined with cognitive testing in the diagnosis of mild cognitive impairment (MCI). [Methods] From April 2021 to April 2022, 70 MCI patients (MCI group) and 236 normal cognitive (NC) controls (NC group) were included from the elderly in Shijiazhuang and Xingtai communities. Subjects were tested for the olfactory recognition function, combined with the Boston naming test (BNT), and venipunctured for blood biomarkers β amyloid protein 40 (Aβ40), Aβ42 and phosphorylated tau 217 (p-tau217). The four MCI screening programs, including olfactory features, BNT with olfactory features, olfactory features with blood Aβ40, and BNT with blood Aβ40 were set as screening schemes. The accuracy sensitivity and specificity of MCI recognition were analyzed by receiver operating characteristic (ROC) curve. [Results] The sensitivity of olfactory feature alone was 61.7%, the specificity was 80.0%, and the area under the curve (AUC) was 0.727. The sensitivity of olfactory features with BNT was 75.0%, specificity was 73.8%, and AUC was 0.788. The olfactory feature combined with blood biomarker Aβ40 had a sensitivity of 51.6% and specificity of 83.5% in identifying MCI, and AUC was 0.709. The BNT combined with blood biomarker Aβ40 had a sensitivity of 61.1% and specificity of 84.6% in identifying MCI, and AUC was 0.770. [Conclusion] For the screening of suspected MCI in the community, olfactory features combined with BNT can improve the sensitivity and specificity, and BNT combined with blood Aβ40 can also improve the specificity of MCI recognition.
Authors and Affiliations
Yaxin HUO, Lan WANG, Wei LIANG, Hao GENG, Xinyang JING, Xuemeng WANG, Anqi HUANG, Zhe YU, Cuixia AN
Keywords
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- EP ID EP750421
- DOI 10.3969/j.issn.1002-0152.2024.02.003
- Views 61
- Downloads 0
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