Gender differences in the impact of modified electroconvulsive therapy on cognitive function in middle-aged and young patients with depression
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 6
Abstract
ObjectivePreliminary exploration of the effects of modified electroconvulsive therapy (MECT) on cognitive function and gender differences in middle-aged and young patients with depressive episodes.MethodsA group of middle-aged and young patients with depressive episodes, who were admitted to Beijing Anding Hospital affiliated to Capital Medical University, completed 6 rounds of MECT. The 17-item Hamilton depression scale (HAMD-17), Hamilton anxiety scale (HAMA), and repetitive battery for the assessment of neuropsychological status (RBANS) were used to score depressive symptoms, anxiety symptoms, and cognitive function at baseline, after the 3rd MECT, and after the 6th MECT, respectively. Gender differences were compared between the young and middle-aged groups.ResultsA total of 122 patients with depressive episodes were included, with 83 cases in the youth group and 39 cases in the middle-aged group. There was no gender difference in baseline HAMD and HAMA scores, as well as the HAMD reduction rates after MECT between the two groups (P>0.05). Repeated measures ANOVA showed that in the youth group, the time effects of RBANS total score, visual breadth factor score, and attention factor score were significant (P<0.05), and increased after treatment compared to baseline. There was no significance in gender group effects or interaction effects (P>0.05). In the middle-aged group, the time and gender interaction effect of RBANS total score and visual breadth factor score was significant (P<0.05). Female patients showed an increase in RBANS total score, visual breadth factor score, and attention factor score after the 6th MECT compared to baseline (P<0.05), while there was no significance in time effect and gender group effect (P>0.05).ConclusionMiddle-aged and young depressed patients showed overall improvement in cognitive function after MECT, while there were gender differences in cognitive function changes among middle-aged patients. It is necessary to optimize the MECT program based on the patientâs gender and age characteristics to reduce cognitive impairment.
Authors and Affiliations
SUN Qian,JIANG Wei,LI Yanru,WANG Nan,HOU Lengbing,REN Yanping. ,
Keywords
Related Articles
- EP ID EP750006
- DOI -
- Views 63
- Downloads 0
An intervention study of right unilateral modified electroconvulsive therapy for major depressive disorder
ObjectiveTo explore the effect and safety of right unilateral modified electroconvulsive therapy (RUL-MECT) for major depressive disorder patients (MDD).MethodsA randomized controlled trial was conducted on 70 patients w...
Advances on the mechanisms of metformin in improving cognitive impairment in schizophrenia
Schizophrenia is a common chronic mental disorder. Cognitive dysfunction is one of its core symptoms , which severely affects the social functioning of patients. Currently, antipsychotic medication treatments have poor e...
Construction of diagnostic model of depression in insomnia patients based on polysomnography data
[Objective] To establish a diagnostic model for depression in insomnia patients by mining polysomnography (PSG) data of insomnia patients with machine learning algorithms, and to provide a scientific basis for the diagno...
Analysis of the efficacy of modified electroconvulsive therapy in schizophrenia patients across different genders
[Objective] To Investigate the efficacy of modified electroconvulsive therapy (MECT) in patients with schizophrenia across different genders. [Methods] From May 2018 to August 2022, 481 patients with schizophrenia were r...
Mid-to-long-term quality of life and psychological status after endovascular embolization of unruptured intracranial aneurysms
[Objective] To investigate whether embolization surgery can improve mid-to-long-term outcomes related to quality of life, anxiety and depression in patients with unruptured intracranial aneurysms (UIA). [Methods] This pr...