A CHEAP METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF ACAMPROSATE CALCIUM IN TABLETS USING UV SPECTROPHOTOMETRY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: To develop a cheap and a rapid UV spectrophotometric method for the quantitative estimation of Acamprosate calcium (333mg) in tablets and validate as per ICH guidelines.Methods: The optimized method uses 100% distilled water as a solvent for the estimation of assay of Acamprosate calcium in tablets at a detection wavelength of 208 nm.Results: The developed method resulted in Acamprosate calcium exhibiting linearity in the range 30-90μg/ml. The precision is exemplified by relative standard deviation of 0.425%. Percentage Mean recovery was found to be in the range of 98â€102, during accuracy studies. The limit of detection (LOD) and limit of quantitiation (LOQ) were found to be 66mg/ml, and 200 mg/ml respectively. Conclusion: A cheap and a rapid UV spectrophotometric method was developed and validated for the quantitative estimation of Acamprosate calcium in tablets as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.Â
Authors and Affiliations
Vijay Kumar Dandu, Swetha Parupugalla, Chandra Mohan Thota, Ashok Kumar Akuthota
Keywords
Related Articles
- EP ID EP579730
- DOI -
- Views 56
- Downloads 0
EVALUATION OF ANTIDEPRESSANT ACTIVITY OF HERBOMINERAL FORMULATION
Objective: In the search for new therapeutic products for the treatment of neurological disorders, medicinal plant research, worldwide, has constantly progressed, demonstrating the pharmacological effectiveness of differ...
SOLID PHASE MICROBIAL REACTIONS OF SEX HORMONE, TRANS-ANDROSTERONE WITH FILAMENTOUS FUNGI
Objective: A microbial biotransformation study was performed on trans-androsterone (1) using solid phase medium. In the present context, trans-androsterone (1), a sex hormone was fermented with two filamentous fungi, Rhi...
RARE SURVIVAL AFTER SEVERE ALUMINIUM PHOSPHIDEPOISOININGAFTER MYOCARDITISWITH L-CARNITINE AND STEROID
Acute Aluminium Phosphide or Celphos poisoning is a common agrochemical fumigant used commonly in countries like South East Asia and China. It is extremely lethal poison as there is no specific antidote and involvement o...
ANTIBACTERIAL EFFECTIVENESS OF SELECTED MOROCCAN ESSENTIAL OILS AGAINST THE HIGHLY VIRULENT JP2 CLONE OF AGGREGATIBACTER ACTINOMYCETEMCOMITANS
Objective: Aggregatibacter actinomycetemcomitans (Aa) serotype b JP2 clone is a highly virulent strain, considered as a major etiologic agent in aggressive periodontitis in patients of African descent, such as Moroccan a...
EFFECT OF SUGNIL, A TRADITIONAL ANTIDIABETIC HERBAL FORMULATION ON THE EXPRESSION OF TRANSCRIPTION FACTORS IN STREPTOZOTOCIN DIABETIC RATS.
Objective: A number of large randomized clinical trials demonstrated that lipid lowering successfully reduced cardiovascular events and death in patients with diabetes. Recent studies have reported that multiple transcri...