A CHEAP METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF ACAMPROSATE CALCIUM IN TABLETS USING UV SPECTROPHOTOMETRY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: To develop a cheap and a rapid UV spectrophotometric method for the quantitative estimation of Acamprosate calcium (333mg) in tablets and validate as per ICH guidelines.Methods: The optimized method uses 100% distilled water as a solvent for the estimation of assay of Acamprosate calcium in tablets at a detection wavelength of 208 nm.Results: The developed method resulted in Acamprosate calcium exhibiting linearity in the range 30-90μg/ml. The precision is exemplified by relative standard deviation of 0.425%. Percentage Mean recovery was found to be in the range of 98â€102, during accuracy studies. The limit of detection (LOD) and limit of quantitiation (LOQ) were found to be 66mg/ml, and 200 mg/ml respectively. Conclusion: A cheap and a rapid UV spectrophotometric method was developed and validated for the quantitative estimation of Acamprosate calcium in tablets as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.Â
Authors and Affiliations
Vijay Kumar Dandu, Swetha Parupugalla, Chandra Mohan Thota, Ashok Kumar Akuthota
Keywords
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