EVALUATION OF ANTIDEPRESSANT ACTIVITY OF HERBOMINERAL FORMULATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 4
Abstract
Objective: In the search for new therapeutic products for the treatment of neurological disorders, medicinal plant research, worldwide, has constantly progressed, demonstrating the pharmacological effectiveness of different plant species in a variety of animal models. SOBEREX CAPSULE (SC) is a herbomineral formulation used by ayurvedic practitioners for treatment of depression. The present study was designed to generate scientific evidence for SC in animal models of depression in mice.Methods: The formulation was administered orally to the mice at a dose of 50 mg/kg for 14 d, and at the end of treatment animals were subjected to tail suspension test and the forced swimming test in mice.Results: The effect of SC at the dose of 50 mg/kg was comparable to that of reference antidepressant fluoxetine. The formulation and fluoxetine, at the doses tested, produced no significant effects on locomotor activity. These results demonstrated that SC had antidepressant effects without side effect.Conclusion: Thus, SC possesses antidepressant-like effects in mice, providing further support for the traditional use of the formulation against central nervous disorders.Keywords: Antidepressant, Herbomineral formulation, Forced swim test, Tail suspension test
Authors and Affiliations
Snehal S. Patel, Niti Rajshree, Praboth V. Shah
Keywords
Related Articles
- EP ID EP577706
- DOI -
- Views 45
- Downloads 0
THE ANTI–ANGIOGENIC ACTIVITY OF PHOENIX DACTYLIFERA SEEDS EXTRACTS
Objective: To identify the possible anti–angiogenic activity of Phoenix dactylifera seeds extract.Methods: The powder of the date palm seeds was extracted sequentially with petroleum ether, chloroform, methanol and wat...
IN VITRO BIOMOLECULAR PROTECTIVE EFFECT OF CINNAMOMUM ZEYLANICUM BARK EXTRACTS AGAINST OXIDATIVE DAMAGE
Objective: Free radicals play an important role in the pathogenesis of many disorders by damaging important biomolecules such as lipids, proteins and DNA. Natural antioxidants are safer, cheaper and potential therapeutic...
PREPARATION AND EVALUATION OF METRONIDAZOLE SUSTAINED RELEASE FLOATING TABLETS
Objective: The objective of the present study is the preparation of metronidazole (MZ) floating tablets that are designed to retain in the stomach for a long time for better eradication of Helicobacter Pylori (H. pylori)...
BIOINFORMATIC CHARACTERIZATION OF SOD UNDER UV IN FENUGREEK (FAMILY: FABACEACE)
Objective: To perform In silico analysis of superoxide dismutase (SOD) of the Fabaceae family along with the assessment of its physiological significance under UV irradiation in fenugreek belongs to the same family.Metho...
THE INFLUENCE OF ADDING ANTIBIOTIC IN TREATMENT OF RHEUMATOID ARTHRITIS PATIENTS ON STREPTOCOCCUS PYOGENES CARRIER RATE AND ON THE LIPIDS PROFILE
Objective: The main goal is to evaluate the clinical efficacy, safety, and tolerability of antibiotics and methotrexate (MTX) treatment on the disease severity, on Streptococcus pyogenes carrier rate and on the lipid pro...