A Clinical Comparative Study of Pre-Emptive Analgesia by Intranasally Instilled Ketamine Vs Fentanyl in Endoscopic Nasal Surgery
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 2
Abstract
This study was undertaken for the study of preemptive analgesic effects of intranasal ketamine and intranasal fentanyl in patients undergoing endoscopic nasal surgery. Material and Method: Patients were allocated in one of the following three groups. Group C for Intranasal Normal saline (3ml) as control group, Group F for Intranasal Fentanyl (2mcg/kg) and Group K for Intranasal Ketamine (1.5mg/kg). All patients observe for intraoperative hemodynamic monitoring and in postoperative visual analoge pain score,rescue analgesia requirements and possible side effects. Results: In our study, we found results in the following order for the three groups:- VAS scoring : Group C > Group K > Group F; Sedation scoring : Group K > Group C > Group F; Total rescue analgesic requirements : Group C > Group K > Group F; Time to first analgesic requirement : Group K > Group F > Group C; Total side effects : Group K > Group F > Group C. Conclusion: Postoperative analgesia was best in intranasal fentanyl group, sedation was maximum in intranasal ketamine group, adverse effects although minimal, were mostly observed in intranasal ketamine group. Intranasal fentanyl group showed good cardiovascular stability during perioperative period as compared to the other two groups. Fentanyl and ketamine both produced significant post-operative analgesia in good number of patients without any significant adverse effects. Hence, they are recommended for use in post-operative analgesia by intranasal instillation in nasal endoscopic surgeries.
Authors and Affiliations
Manoj Kumar Giri
Keywords
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- EP ID EP466436
- DOI 10.21088/ijaa.2349.8471.42(pt.II)17.26
- Views 96
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