A Clinical Evaluation of the Intubating Conditions using two Different Doses of Rocuronium and its Comparison with Succinylcholine for Rapid Sequence Induction: A Prospective Single Blind Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Succinylcholine is the gold standard for rapid sequence induction. However its use is associated with many adverse effects so the search for an ideal neuromuscular blocking agent was done. Rocuronium is the only drug currently available which has the onset of action similar to that of succinylcholine and is devoid of any adverse effects that are commonly seen with succinylcholine. So the aim of this study was to evaluate rocuronium as a muscle relaxant using two different doses for rapid sequence endotracheal intubation and compare it with succinylcholine. Material and Methods: Ninety patients were divided into three groups of 30 each. Groups A received injection succinylcholine at 1.5 mg/kg, Groups B and C received rocuronium 0.6 mg/kg and 0.9 mg/kg respectively. Onset of action of relaxant, intubation conditions, intubation score and duration of action were compared. Results: The onset time was significantly shorter with succinylcholine 1.5 mg/kg in comparison to rocuronium 0.9 mg/kg and 0.6 mg/kg. Intubating conditions were excellent with succinylcholine 1.5 mg/kg and rocuronium 0.9 mg/kg in comparison to rocuronium 0.6 mg/kg. Conclusion: Rocuronium in the dose of 0.9 mg/kg should definitely be given preference over succinylcholine in conditions, where the use of succinylcholine is hazardous.
Authors and Affiliations
Rohan Bhandari, A. P. Verma, Ram Pal Singh, Malti Agrawal, Gopal Krishan, Subhro Mitra
Keywords
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