A clinical study of feto-maternal outcome of tocolytic agent nifedipine as compared to Isoxsuprine Hydrochloride in preterm labour
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 9
Abstract
Introduction: Preterm labor and delivery is one of the biggest challenges for obstetricians and so are the preterm babies for the pediatricians. Preterm delivery affects 11% in U.S. or even greater in developing countries (23.3% in India) and it accounts for 40–75% of neonatal deaths. Incidence of preterm labor and delivery shows increasing trends in countries where data is available Aims and Objectives: To find out foetal and maternal outcome in the study group and to compare its efficacy with Isoxsuprine Hydrochloride. Methodology: A one-year study was undertaken in the department of Obstetrics and Gynaecology Assam Medical College and Hospital, Dibrugarh from 1st August 2005 – 31st July 2006, to find the tocolytic efficacy of Nifedipine and its foeto-maternal outcome and to compare clinically the efficacy with that of Isoxsuprine Hydrochloride. This was a Randomized Clinical Study. 100 patients with preterm labour were included in the study randomly. Result: The mean time taken to lessen or stop uterine contractions sufficiently was significantly less in the Nifedipine Group (1.64±1.015 hrs) than in the Isoxsuprine Group (11.94±10.557 hrs). p<001.There is a significant difference between the mean prolongation of pregnancy by Nifedipine (46.13±17.78 days) and by Isoxsuprine (27.35±20.60 days). p<0.001 which is very highly significant. The mean birth weight in Nifedipine group was 2.618±0.366 kg and in Isoxsuprine 2.156±0.624 kg. This observed difference was highly significant. Maternal Mortality was nil in both the groups. The Perinatal mortality was 1(2%) in Nifidipine , was significantly lower as compared to Isoxsuprine group 8 (16%).The successful tocolytic effect was significantly higher in Nifedipine group(100%) as Compared to Isoxsuprime (70%). Conclusions: In our study we have found Nifedipine as a better, safer and effective tocolytic compared to Isoxsuprine in the management of preterm labour.
Authors and Affiliations
Farzana Zahir, Kalyan Kumar Nath, H H Choudhury
Keywords
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