A CLINICAL STUDY OF HORMONE RECEPTOR STATUS IN CARCINOMA BREAST
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 52
Abstract
BACKGROUND The world’s most common cancer and the second main cause of cancer death among women in the United States is breast cancer. Breast cancer is the second most common cancer among women in India after carcinoma cervix. A single parameter with the strongest prognostic significance is hormone receptor status. Intracellular steroid-hormone receptor proteins, primarily Oestrogen Receptor (ER) and Progesterone Receptor (PR) have received intensive study both as indicator of prognosis and as guide to hormone therapy. Recently, importance of HER2/neu in breast cancer has been a topic of considerable interest, both in its role as a prognostic indicator and as a predictor of response to therapy. The aim of the study is to assess the incidence of hormone receptor positivity in females with carcinoma breast and to compare hormonal receptor status with clinicopathological grading of the tumour. MATERIALS AND METHODS A study of cases of carcinoma breast in females were done. Sample included 75 patients. Patients for clinical study were selected from the general surgical wards of Tirunelveli Medical College Hospital for a period of 18 months. RESULTS Out of 75 patients, 52 patients (69.33%) were positive for oestrogen receptor and 23 (30.66%) were negative. 39 patients (52%) were progesterone receptor positive and 36 (48%) were progesterone receptor negative. 28 (37.33%) patients had Her2 receptor positive and 47 (62.66%) were negative. CONCLUSION These results were comparable with the previous studies and thus reinforce the usefulness of estimation of the receptor status for treatment purpose in breast carcinoma.
Authors and Affiliations
Josephine Pudhumai Selvi, Sivanupandian Sivasubramanian, Karthik Manohar
Keywords
Related Articles
- EP ID EP220283
- DOI 10.18410/jebmh/2017/635
- Views 111
- Downloads 0
AGE AND SEX RELATED CHANGES ON RR INTERVAL AND ST HEIGHT IN ELECTROCARDIOGRAM (ECG) OF HEALTHY INDIVIDUALS
BACKGROUND AND OBJECTIVES: With advancing age, degenerative changes occur in heart muscle and its conduction system. This study was undertaken to see the ECG changes in different age groups of healthy adults. MATERIALS &...
A SIMPLE PULMONARY RECRUITMENT MANOEUVRE TO REDUCE SHOULDER TIP PAIN AND POSTOPERATIVE NAUSEA AND VOMITING AFTER GYNAECOLOGICAL LAPAROSCOPIC SURGERY- A RANDOMIZED CONTROLLED STUDY
BACKGROUND To study the efficacy of pulmonary recruitment manoeuvre for removal of residual abdominal carbon dioxide after laparoscopic surgery to reduce shoulder pain and postoperative nausea and vomiting (PONV). METHOD...
A STUDY ON MORPHOMETRY OF ARTICULAR CARTILAGE OF TIBIOFIBULAR MORTISE
Talocrural joint is a major weight bearing joint of the body. The objective of the study is to find the mean measurements of the articular cartilage of the tibiofibular mortise in south Indian population, differences bet...
HETEROTOPIC OSSIFICATION OF HIP IN A RARE CASE OF MOYAMOYA DISEASE: A RARE CASE REPORT
A case of extensive ossification around the left hip joint involving lesser trochanter of the femur leading to ankylosis of left hip joint in a 60 years male is being reported. The diagnosis of moyamoya disease was made,...
COMPARISION OF DEXMEDETOMIDINE AND CLONIDINE WITH ROPIVACAINE BY EPIDURAL ROUTE IN PATIENTS UNDERGOING LOWER ABDOMINAL SURGERIES
BACKGROUND Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or as described in terms of such damage. Regional anesthetic procedure is a need for local anesthetic wi...