A clinical study on profile of the patients experiencing extra-pyramidal side-effects with the Usage of second generation antipsychotics Effects of second generation antipsychotics
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 6
Abstract
Abstract: There were claims that second generation antipsychotics (SGA) producefewer extra-pyramidal symptoms (EPS) and their EPS profiles were compared.The aim is to compare the treatment emergent EPS and efficacy profile betweenolanzapine, risperidone, iloperidone and asenapine in people with psychoticdisorders.The clinical comparative study was undertaken at Department of Psychiatry, SriVenkateshwara Ramnarayana Ruia Hospital, Tirupathi. Total 120 patients diagnosedto be suffering from psychotic disorders were enrolled in this study after obtainedwritten informed consent. They are treated alternately primarily with the 4 drugsi.e. olanzapine, risperidone, iloperidone and asenapine. They were regularlyfollowed-up for 3 months for EPS and efficacy by using standardized rating scales.Patients were requested to attend regular follow-ups at 2 weeks, 4 weeks,8weeks and 12 weeks interval. Iloperidone dose was titrated over 6-10 days toreach its maximum dose. Specific instructions were given for asenapine in itssublingual administration.There were no significant differences in occurrence or changes in ratingscales for parkinsonism, akathisia or tardive dyskinesia among the 4 drugs.Therewere also no significant differences in change in BPRS scores from baselineamong the 4 drugs.The occurrence of treatment emergent EPS and changes in EPS rating scalesindicated that all the 4 drugs were similar to each other in causing EPS. Regardingefficacy, this study concludes that all the 4 drugs were similar to each other in theirefficacy profile in treatment of psychotic disorders. Keywords:antipsychotics,olanzapine, risperidone, iloperidone.
Authors and Affiliations
Aruna, DNB (PSY), DPM, Y. Veerabhadram, B. Rajsekhar
Keywords
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