Haemodynamic effects of low dose Dexmedetomidine infusion in patients undergoing laparoscopic cholecystectomy –A randomized study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 5
Abstract
Laparoscopic surgery had several advantages over conventional surgery for the patient. Dexmedetomidine due to its distinct properties can be used as an anaesthetic adjuvant in the form of intravenous infusion. We studied the use of low dose dexmedetomidine infusion in laparoscopic surgery and its effect on hemodynamics, sedation scores and analgesic requirements. After the approval of the hospital ethics committee of Mahatma Gandhi Memorial Hospital Warangal, Telangana state 90 patients, aged 25 to 52 years, ASA grade I to II, and scheduled for laparoscopic cholecystectomy, were included in the study. Control Group C received normal saline0.9%, Group D1received dexmedetomidine 0.2 μg/kg/h and Group D2 received dexmedetomidine 0.4μg/kg/ h intravenously. There was no significant difference in preoperative hemodynamic parameters between the groups. In control Group significant haemodynamic stress response was seen following laryngoscopy, tracheal intubation, creation of pneumoperitoneum and extubation. Index medetomidine groups, the haemodynamic response were significantly attenuated. In addition, dexmedetomidine provides lighter sedation and reduces the post‑operative analgesic requirements without any significant adverse effects. Dexmedetomidine 0.4mcg/kg/h was significantly more effective than 0.2mcg/kg/h and control group. Keywords: Laparoscopy, Cholecystectomy, Dexmedetomidine, Haemodynamic response, Analgesia.
Authors and Affiliations
Laxmi Narsaiah G, Murali. CH, Srinivasa Rao. B, Praveen Kumar. D, Sravan Kumar. G
Keywords
Related Articles
- EP ID EP371311
- DOI -
- Views 52
- Downloads 0
A comparative study between transdermal patches of Buprenorphine andFentanyl for postoperative pain relief following orthopaedic surgery underregional anaesthesia
Abstract: Transdermal buprenorphine and fentanyl is commonly used for chronic pain management. Our aim was to evaluate the efficacy of transdermal buprenorphine and fentanyl patch in postoperative acute pain management.A...
Hemodialysis induced trace elements level variations among chronic renal failure patients
Renal disease is a common cause of death and disability in many countries throughout the world. End-Stage Renal Disease (ESRD) is the final stage of CRF characterized by progressive, irreversible deterioration in renal f...
Comparative Study between Exteriorization of Uterus during Cesarean Section Versus Intraperitoneal or in-Situ Repair
The objectives of this study is to assess intraoperative and postoperative advantages and disadvantages following exteriorization of uterus as compared to those with intraperitoneal or in-situ repair and to assess intra...
To Study the Incidence of Various Intra-Abdominal and Extra-Abdominal Injuries in Blunt Abdominal Trauma at Tertiary Care Centre of Central India
Blunt abdominal trauma (BAT), a common form of trauma, is one of the major causes of morbidity and mortality. The study was aimed at finding the incidence of various intra-abdominal and extra-abdominal injuries in blunt...
Polyhydramnios as a Predictor of Adverse Pregnancy Outcomes: A Case Control Study
Abstract: The aims of our study were to assess the perinatal outcomes associated with polyhydramnios and to determine if there is a relationship between degree of polyhydramnios and risk of these adverse outcomes. Materi...