Utility of Raised Adenosine Deaminase Activity in Cerebrospinal Fluid in the Diagnosis of Tuberculous Meningitis in Children
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 2
Abstract
Abstract: The diagnosis of tuberculous meningitis cannot be made or excluded on the basis of clinical findings. Definite laboratory diagnosis is cumbersome and time consuming. Delay in diagnosis and institution of proper treatment is directly related to poor outcome and squamae. So we have to search for an early diagnostic marker of tuberculous meningitis. Adenosine deaminase activity (ADA) was estimated in cerebrospinal fluid (CSF) in addition to routine CSF analysis. We have selected 32 patients of tuberculous meningitis (TBM), 7 patients of partially treated pyomeningitis (PTM), 10 patients aseptic meningitis (AM) and 13 patients pyogenic meningitis (PM). Mean ADA levels in CSF of TBM patients were higher (15.42 U/L) as compared to 7.21 U/L, 6.41 U/L and 7.50 U/L in PTM, AM and PM respectively. ADA values were also compared with other biochemical and cytological parameters of CSF. This difference of ADA values in CSF between TBM and other types of meningitis was statistically significant (p<0.01). Also, a positive correlation of CSF-ADA was found with CSF protein level. Sensitivity and specificity of ADA levels in CSF of children to diagnose tuberculous meningitis was 75% and 90% respectively at 10 U/L cut off values. Estimation of CSF ADA can be taken as a diagnostic marker of TBM in children.
Authors and Affiliations
Arnab Biswas
Keywords
Related Articles
- EP ID EP474747
- DOI -
- Views 67
- Downloads 0
A Study of Thrombocytopenia in Sick Neonates in a Tertiary Care Centre
Abstract: Thrombocytopenia is the most common haematological abnormality in sick newborns occurring in almost one third of NICU admissions.To study the incidence of thrombocytopenia in sick neonates and its relation with...
Reduced Amniotic Fluid Index– Does It Affect Maternal And Perinatal Outcome In Low Risk Term Pregnancy?
Abstract: To study the Maternal and perinatal outcome in reduced amniotic fluid index (AFI) at term in low risk pregnancies.A Prospective case control study of term, low risk pregnancy, reduced AFI within two study grou...
Effects of lidocaine, fentanyl and esmolol on haemodynamics and bispectral index when used before laryngoscopy and intubation to prevent stress response in patients with etomidate induction
Endotracheal intubation creates a period of hemodynamic instability in normotensive patients. Endotracheal intubation produces stimulation of laryngeal and tracheal sensory receptors, resulting in a marked increase in th...
Comparison of Fetal Malnutrition by CANSCORE and Other Methods
compared to developed countries (5-7%). Preterm babies account for only 10% of LBW babies, the rest being term intrauterine growth retarded infants.The objective of the study was clinical assessment of nutritional status...
Clinical Assessment of the Autonomic Nervous System in Type 2 Diabetes Mellitus and Its Correlation with Glycemic Control, Duration and Microalbuminuria
Abstract:The Clinical assessment of the autonomic nervous system in Diabetes mellitus (DM) and its correlation with glycemic control, duration and microalbuminuria, Cross sectional study of 96 adult diabetes patients. Ni...