A CLINICOPATHOLOGICAL STUDY TO ANALYSE THE IMPORTANCE OF HISTOPATHOLOGICAL EXAMINATION IN DIAGNOSIS OF EXCISED CONJUNCTIVAL LESIONS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 44
Abstract
BACKGROUND Squamous papilloma is a benign tumor that originates from human papillomavirus infection of conjunctiva. This tumor can occur in children and adults. It has a pink fibrovascular frond of tissue arranged in a sessile or pedunculated pattern. A pinguecula is small, yellowish nodule, bilateral and located at the nasal/temporal limbus. On histology, the stromal collagen has fragmentation and basophilic degeneration known as elastotic degeneration as the degenerated collagen stains positively when using histochemical stains for elastic fibre like the Verhoeff–Van Gieson stain. Objectives of this study1. To analyse the importance of histopathological examination in confirming the diagnosis of various conjunctival lesions like ocular surface squamous neoplasia, malignant melanoma, granulomas. 2. To analyse the clinical presentation of various conjunctival lesions and to differentiate between benign and malignant lesions histopathologically (for early diagnosis of malignancy). MATERIALS AND METHODS This is a descriptive study of histopathology of conjunctival lesions from period of June 2015 to October 2017. Data included age, gender, laterality, gross feature, size, scleral fixity, corneal involvement, pain, congenital or acquired, progression, management, recurrence. RESULTS A total of 40 patients presented to our cornea clinic with conjunctival lesions from June 2015 to October 2017, of whom 23 patients were males (57%) and 17 (43%) were females. The age of presentation ranged from 13-70 years. In our study, the patients were clinically classified into eight categories- benign non-pigmented, pre-malignant non-pigmented, malignant non-pigmented, benign pigmented, malignant pigmented, premalignant pigmented, cyst and degeneration. Treatment options include, excision/excision with 3mm tumour free margin biopsy, adjuvant conjunctival autograft, cryotherapy with AMG, corneal alcohol ablation, histopathological examination. In follow-up, recurrence is seen only in three cases of malignant lesions. CONCLUSION In any conjunctival lesion, excision biopsy followed by histopathological examination and regular follow up is mandatory
Authors and Affiliations
Pandiaraj Saravana Sankar, Chandran Indhu, Nataraja Rathinam Sudha Priyadharsini, Manoharan Suhanya, Eswaramoorthy Jeeva, Manimozhi Sundaravathani, Vetrichelvan Dhivya, Chandra Sekar Sangeetha Kala
Keywords
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- EP ID EP549223
- DOI 10.14260/jemds/2018/1055
- Views 98
- Downloads 0
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