A COMPARATIVE EVALUATION OF PULMONARY FUNCTION TESTS IN SICKLE CELL ANAEMIA PATIENTS IN RAIPUR DISTRICT, CHHATTISGARH
Journal Title: International Journal of Basic and Applied Physiology - Year 2014, Vol 3, Issue 1
Abstract
Background: The inherited disorders of haemoglobin are the commonest single gene disorder of the world population. Sickle cell anaemia being the most widespread and numerically the most important haemoglobinopathy in the world today. The major features of sickle cell disease (SCD) in most patients are lifelong anaemia and the consequences of recurrent vaso-occlusion. Many complications of SCD involve anaemia, vaso-occlusion etc. Impairment of pulmonary function is a common complication of SCD. The patients suffering from this disease frequently present with complaints referable to the pulmonary system although other systems are also involved. Hence present study was carried out to evaluate the pulmonary function tests in sickle cell disease patients ( HbSS ),sickle cell trait patients(Hb AS) with normal person ( HbAA) non-sicklers. Aim and Objectives: 1) To study the pulmonary alterations in cases of homozygous SS & heterozygous AS Sickle Cell Disorder subjects.2) To compare the parameters with normal healthy controls & assess the importance of PFT in "Steady State"(free from complications or crisis)as an objective evidence to predict the risk of "Sickle Cell Chronic Lung Disease'' in future. Method: A cross sectional study was done in 50 cases of SCD (22HbSS& 28HbAS) and age and sex matched normal 50 HbAA controls. From the various measured pulmonary function test( PFT )parameters Forced Vital Capacity( FVC),Forced Expiratory Volume in 1 sec(FEV1),FEV1/FVC were selected for the study. The data collected was subjected to statistical analysis involving computation of Mean, Standard deviation, Independent T test. Result: Mean value of FVC, FEV1 and FEV1/FVC were found to be significantly lower than normal controls, but the difference in FVC between HbAS and HbSS turned out to be statistically non-significant whereas the difference in FEV1, FEV1/FVC between HbAS and HbSS was statistically significant. Conclusion: There were significant reductions in pulmonary function test parameters in sickle cell anaemia patients as compared to normal controls indicative of mixed pattern (both restrictive and obstructive) lung impairment in sickle cell anaemia.
Authors and Affiliations
Karishma Singh
Keywords
Related Articles
- EP ID EP547331
- DOI -
- Views 34
- Downloads 0
COMPARATIVE STUDY OF ANKLE BRACHIAL PRESSURE INDEX, LIPID PROFILE AND BLOOD SUGAR IN CYCLE RICKSHAW DRIVERS AND CONTROL SUBJECTS
Background: The ankle brachial pressure index (ABPI) is a non–invasive quantitative measurement for diagnosing Peripheral Arterial Disease (PAD). A high ABPI (>1.2) is associated with increased cardiovascular disease. A...
COMPARISION OF TASTE THRESHOLD PARAMETERS ON PREGNANT AND NON-PREGNANT WOMEN
Background & objectives: Many physiological and behavioural changes take place during pregnancy, including changes in taste and an increase in food intake. These changes are necessary to ensure growth and development of...
LEVEL OF PERCEIVED WORK RELATED STRESS AND ITS EFFECT ON BEHAVIOUR CHANGE IN CALL CENTRE EMPLOYEES
Background & objectives: Generally the call centre industry works in two shifts and companies catering to clients of the western part of world have to work more during the night hours. The expectations from the employees...
INTRODUCTION OF INTEGRATED TEACHING IN I st MBBS: PERSPECTIVE OF STUDENTS
AIMS AND OBJECTIVES: study was carried out to focus on effective and meaningful learning that will help the students’ overall development and to improve the continuity of students’ learning. MATERIAL AND METHOD: 150 stud...
YOGA AS AN EXERCISE TOOL: STUDY OF PHYSIOLOGICAL PARAMETERS OF THE HEALTHY SUBJECTS
Background and Oobjectives: As participation rates in mind-body fitness programs such as yoga continue to increase, it is important for health care professionals to be informed about the nature of yoga and the evidence o...