A Comparative Study between Intrathecal Clonidine and Buprenorphine with Intrathecal Bupivacaine for Lower Abdominal Surgeries
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 1
Abstract
Purpose: Subarachnoid (spinal) block is a safe and effective alternative to general anesthesia when the surgical site is located on the lower extremities, perineum (eg, surgery on the genitalia or anus), or lower body wall (eg, inguinal herniorrhaphy). In no other way, can an anaesthesiologist obtain so much of an effect for the introduction of a small quantity of the drug. Likewise a properly chosen adjuvant to local anaesthetic agent produces the best way to achieve a good quality regional block. Aim of Study: To compare the effect of intrathecal Clonidine 75 micrograms (µg) and Buprenorphine 150 µg with 2.5ml (12.5mg) of intrathecal 0.5% hyperbaric Bupivacaine. With regards to: 1) Sensory characteristics, 2) Motor characteristics, 3) Hemodynamic stability and 4) Side effects. Methodology: A prospective randomized experimental study were performed on 50 patients posted for lower abdominal surgery belonging to ASA I and aged between1860 years after obtaining an informed consent and ethical clearance. Result: Addition of 150 µg Buprenorphine significantly enhances the onset of sensory block (90±15 secs) and motor block (150±15 secs) than compared to Clonidine onset of sensory block(150±20 secs) and motor block(210±20 secs) (p<0.05). Hemodynamic was well maintained with buprenorphine group. And addition of Buprenorphine 150µg to intrathecal Bupivacaine(0.5%) produces prolonged analgesia (526±96) than compared to the Clonidine group of 362±36mins (p<0.05) with no serious adverse effect noted perioperatively in either groups. Conclusion: The addition of Buprenorphine to intrathecal Bupivacaine (0.5%) prolongs the duration of post operative analgesia than compare to clonidine. Buprenorphine has faster onset of sensory and motor blockade than compare to clonidine.
Authors and Affiliations
Yoganarasimha N.
Keywords
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- EP ID EP462928
- DOI 10.21088/ijaa.2349.8471.4117.17
- Views 111
- Downloads 0
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