A Comparative Study of Oral Gabapentin and Oral Clonidine as Preemptive Analgesia under Spinal Anesthesia for Abdomino-Pelvic Surgeries
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2019, Vol 6, Issue 4
Abstract
Aim: To assess the effect of oral Gabapentin and oral Clonidine used as Preemptive analgesia to attenuate postoperative pain in patients undergoing elective Abdomino-Pelvic surgeries under Spinal Anesthesia. Objective: To assess postoperative analgesic benefit, their postoperative efficacy with respect to duration of analgesia and total postoperative requirement and side effects if any of both the groups. Material and Method: 60 patients of either sex of age between 18-65 years, ASA grade I & II, patient admitted to Khaja banda nawaz teaching and general hospital for elective abdominal surgeries under spinal anesthesia were included in the study. The patients were randomly allocated into two groups of 30 each, group G received Gabapentin 300 mg tablet orally 90 min before surgery, group C received clonidine 100 μg tablet orally 90 min before surgery. Duration of postoperative analgesia, Degree of postoperative pain (VAS score) and added rescue analgesia required in 24 hrs were recorded postoperatively. Result: Analysis revealed the postoperative analgesic efficacy of oral Gabapentin showed better pain tolerance compared to that of oral Clonidine. The Ramsay sedation score showed a significant sedative effect by Gabapentin than in Clonidine at 90 mins, haemodynamic parameters changes suggested Gabapentin to be haemodynamically stable than clonidine, Morphine consumption in 24 hrs was significantly high in Clonidine group with increased incidence of nausea and vomiting. Conclusion: Oral Gabapentin 300 mg given before 90 minutes as preemptive analgesia was more effective in reducing postoperative pain and morphine consumption, also providing better anxiolysis in patients undergoing abdomino-pelvic Surgeries under spinal anesthesia compared to Oral Clonidine 100 μg.
Authors and Affiliations
Ankita Hajare
Keywords
Related Articles
- EP ID EP667962
- DOI 10.21088/ijaa.2349.8471.6419.33
- Views 120
- Downloads 0
The Effectiveness of Ondansetron versus Tramadol as Pretreatment in Alleviating Propofol Injection Pain: A Comparative Study
Introduction: Propofol is widely used for induction of anesthesia, although the pain during its injection remains a concern for all anesthesiologists. A number of techniques have been adopted to minimize propofol-induced...
Postoperative Outcome of High Risk Patients in the Intensive Care Unit: A Retrospective Study
Background: This study was to evaluate the postoperative clinical outcome of high risk surgical patients admitted to Intensive Care Unit (ICU). Methodology: This retrospective study reviewed the details of all the 501 po...
An Observational Study to Compare Intrathecal Midazolam and Clonidine for Post Operative Analgesia in Patients Undergoing Elective Hernia Surgeries
This observational study is designed to compare the intrathecal preservative free midazolam and clonidine, used as an adjuvant with hyperbaric bupivacaine for post operative analgesia in patients undergoing elective her...
Comparative Evaluation of Intravenous Granisetron Hydrochloride and Intravenous Lignocaine Hydrochloride to Alleviate the Pain on Propofol Injection
Propofol is one of the most commonly used induction agent. Pain on injection still remains a considerable concern for anaesthesiologist. The aim of the study was to assess the efficacy of granisetron HCL and ligocaine HC...
Is General Anaesthesia with Paediatric Epidural Anaesthesia Superior to General Anaesthesia Alone in Improving Postoperative Outcome?: A Clinical Study
Background: Paediatric epidural anaesthesia and analgesia (PEA) is being accepted as a standard method of advanced pain management as epidural catheter offers the advantage of excellent long term post-operative analgesia...