A Comparative Study of Angiogenesis and Lymphangiogenesis as Prognostic Indicators in Epithelial Ovarian Carcinoma
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Ovarian cancer is the sixth most common cancer and the seventh leading cause of cancer death among women worldwide with 90% of them being of epithelial origin. Its early detection is difficult due to the lack of specificity of clinical symptoms and effective screening procedures, with a 5-year survival rate of ovarian cancer being only 30% approximately. Study aimed to evaluate Angiogenesis and Lymphangiogenesis as Prognostic Indicators in Epithelial Ovarian Carcinoma. IHC evaluation of intra & peritumoral Lymphangiogenesis and Angiogenesis in 25cases of EOC with histological type, grade & stage. Material and Methods: This was a retrospective study comprising of 25 cases of epithelial ovarian carcinoma diagnosed over a period of 2 years. Quantification of tumor vascularisation by IHC for Lymphangiogenesis was assessed by marker D2-40 and Angiogenesis by CD 34 in 25 patients of Epithelial Ovarian Carcinoma. Morphological aspects such as histological type, grades, stage of cancer as well as vessel distribution that is peritumoral and intra tumoral and vessel density were analyzed. Result: LVD in peritumoral areas was associated with type, grade & stage of EOC.Cancer induced lymphangiogenesis may be related to microenvironment in tumor infiltrating areas. MVD demonstrated close relation with FIGO stage, grade &type of EOC. Conclusion: Angiogenesis &lymphangiogenesis may be of significant prognostic value in predicting clinical outcome and future therapeutic measures.
Authors and Affiliations
Nirupma Lal, Parul Gupta, Neema Tiwari, Samreen Naqash, H. P. Gupta, A. N. Srivastava
Keywords
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