A Comparative Study of Angiogenesis and Lymphangiogenesis as Prognostic Indicators in Epithelial Ovarian Carcinoma

Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 3

Abstract

Introduction: Ovarian cancer is the sixth most common cancer and the seventh leading cause of cancer death among women worldwide with 90% of them being of epithelial origin. Its early detection is difficult due to the lack of specificity of clinical symptoms and effective screening procedures, with a 5-year survival rate of ovarian cancer being only 30% approximately. Study aimed to evaluate Angiogenesis and Lymphangiogenesis as Prognostic Indicators in Epithelial Ovarian Carcinoma. IHC evaluation of intra & peritumoral Lymphangiogenesis and Angiogenesis in 25cases of EOC with histological type, grade & stage. Material and Methods: This was a retrospective study comprising of 25 cases of epithelial ovarian carcinoma diagnosed over a period of 2 years. Quantification of tumor vascularisation by IHC for Lymphangiogenesis was assessed by marker D2-40 and Angiogenesis by CD 34 in 25 patients of Epithelial Ovarian Carcinoma. Morphological aspects such as histological type, grades, stage of cancer as well as vessel distribution that is peritumoral and intra tumoral and vessel density were analyzed. Result: LVD in peritumoral areas was associated with type, grade & stage of EOC.Cancer induced lymphangiogenesis may be related to microenvironment in tumor infiltrating areas. MVD demonstrated close relation with FIGO stage, grade &type of EOC. Conclusion: Angiogenesis &lymphangiogenesis may be of significant prognostic value in predicting clinical outcome and future therapeutic measures.

Authors and Affiliations

Nirupma Lal, Parul Gupta, Neema Tiwari, Samreen Naqash, H. P. Gupta, A. N. Srivastava

Keywords

Related Articles

Histopathological Patterns of Endobronchial Lung Biopsy Specimen in Lung Cancer along with Clinico - Radiological Correlation

Introduction: Lung cancer is one of the commonest lethal cancers known till date. Along with the typical symptomatic clinical presentation, it is appropriately detected by various radiographic evaluation methods sometime...

Epidemiology, Clinical Spectrum and Outcomes of Fungal Sepsis in Neonates in Neonatal Intensive Care Unit: A Prospective Observational Study

Introduction: With the advancement in the management of newborn there has been significant improvement in the survival of prematurely delivered newborns. Study aimed to describe the epidemiology of fungal sepsis in neona...

Role of Flexible Intramedullary Nailing in Pediatric Femoral Shaft Fractures

Introduction: Flexible nailing is a safe and effective method of treatment of pediatric femoral shaft fractures study aimed to observe results of flexible intramedullary nailing in pediatric femoral shaft fractures. Mate...

RHINO-Cerebral Mucormycosis in an Immunocompetent Patient

Introduction: Mucormycosis is a rare fungal infection in an immunocompromised patient. It is even rarer in an immunocompetent patient presenting as nasal polyp. This case is presented for its rarity. Case report: a 48 ye...

Mean Platelet Volume as Predictor of Sepsis

Introduction: Neonatal sepsis is one of the most common causes of NICU admission and one of the major causes of morbidity and mortality throughout the world. Objective of the study was to study organism-specific platelet...

Download PDF file
  • EP ID EP427219
  • DOI -
  • Views 138
  • Downloads 0

How To Cite

Nirupma Lal, Parul Gupta, Neema Tiwari, Samreen Naqash, H. P. Gupta, A. N. Srivastava (2017). A Comparative Study of Angiogenesis and Lymphangiogenesis as Prognostic Indicators in Epithelial Ovarian Carcinoma. International Journal of Contemporary Medical Research, 4(3), 669-675. https://europub.co.uk/articles/-A-427219