A comparative study of central corneal thickness in normal, primary open angle glaucoma and ocular hypertension

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A comparative study of central corneal thickness in normal, primary open angle glaucoma and ocular hypertension

Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 5

Abstract

Purpose: The present study was undertaken with the following Aims and Objectives: To determine the relationship of central corneal thickness and accuracy of intraocular pressure measured by applanation tonometry in normal, Primary open angle glaucomatous and ocular hypertensive eyes. To determine whether, in our population, patients classified as "ocular hypertensive" did indeed have thicker cornea compared to normal subjects or true glaucoma patients. Material and Method: This is a Hospital Based Prospective Comparative study conducted in Eye Department, SMS Hospital, Jaipur. Sample consisted of 50 patients in which 20 were Normal, 20 were POAG patient and 10 Ocular Hypertensive patient. On the basis of formula the minimum no. of patients required in each group is 10. To increase the accuracy 20 pt in Normal group and 20 in POAG gp were included. As Ocular Hypertensives comparatively less so minimum of 10 patients were included. In all patient IOP was done by Goldmann applanation tonometer and CCT was measured by Mentor A Scan ultrasonic Pachymeter. A correction factor formula for correcting IOP to adjust for CCT measurements that differs from normal CCT is proposed. Results: In our study the mean measured IOP was 13.06 mm Hg, 19.69 mm Hg and 25.96 mm Hg in three groups respectively. The mean CCT was 537m, 534 m and 574 m respectively in three groups. The mean corrected IOP was 11.84, 18.69 and 22.10 mm Hg respectively. After applying correction IOP formula The change in IOP group III was statistically significant (P< 0.001) while the change in group II was not statistically significant (P>0.05). Conclusion: A definite relationship of IOP and CCT was found. In this study, after correcting the IOP with CCT, about 40% patients of OHT group comes under normal category with their corrected IOP less than the 'magic 21mm Hg IOP. We suggest that measurement of C.C.T. should be part of routine work up of patients with glaucoma and those suspected of having glaucoma and central corneal thickness should be measured in patients in whom I.O.P.s do not correspond to other clinical findings. This will help to prevent the erroneous labeling of normal patients as "ocular hypertensives".

Authors and Affiliations

Vivek Jain, Manish Sharma, Rajeev Yadav

Keywords

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EP ID EP206564
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