A COMPARATIVE STUDY OF CLINICAL EFFECTS OF INTRATHECAL 0.5% BUPIVACAINE WITH CLONIDINE VERSUS 0.5% BUPIVACAINE IN PATIENTS UNDERGOING MAJOR GYNAECOLOGICAL SURGERIES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 30
Abstract
Spinal anaesthesia requires a small volume of drug to produce profound sensory analgesia and motor blockade but has limited duration of action. So a properly chosen adjuvant to local anaesthetic agent produces the best way to achieve a better quality regional block. Hence the present study was undertaken to compare the effects of intrathecal clonidine (30µg) and placebo, when administered together with hyperbaric bupivacaine 0.5% for major gynaecological surgeries like Total Abdominal hysterectomy, vaginal hysterectomy, and Manchester repair.100 patients posted for elective major gynaecological surgeries were selected and allocated randomly into two groups. Each group of 50 patients. Group I:- 0.5% of Hyperbaric Bupivacaine (17.5mg) + placebo Group II: - 0.5% of Hyperbaric Bupivacaine (17.5mg) + clonidine(30µg). Onset of sensory block, motor block, quality of analgesia, duration of analgesia and duration motor blockade between two groups were compared and contrasted. Patient vitals like Pulse rate, Blood pressure, Respiratory rate, SPO2 and ECG were monitored during the study. During the study observed for the side effects like Nausea, Vomiting, Hypotension, Bradycardia, and dryness of mouth. CONCLUSIONS: Are Quality of analgesia is excellent in patients receiving clonidine when compared to placebo group. Total duration of analgesia and motor blockade was significantly prolong in clonidine group compared to placebo group. Minimal side effects like mild hypotension, mild sedation, and dryness of mouth were seen in clonidine group which does not require any active intervention
Authors and Affiliations
Penchalaiah C. H. , Manoj Kumar G.
Keywords
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- EP ID EP228929
- DOI 10.18410/jebmh/2015/627
- Views 80
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