RELATIONSHIP OF PROINFLAMMATORY CYTOKINES WITH MICROALBUMINURIA IN PATIENTS OF TYPE 2 DIABETES MELLITUS- IMPLICATIONS IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 10
Abstract
BACKGROUND Type 2 diabetes mellitus is frequently associated with an increased inflammatory state. However, the relationship between of low grade inflammation and diabetic nephropathy still remains unclear with conflicting results. We therefore intended to analyse the inter-relationships between pro inflammatory cytokines and renal functions with respect to the glycemic status in type 2 diabetes mellitus patients. MATERIALS AND METHODS 89 type 2 Diabetes mellitus patients and 26 age matched healthy controls were studied (29 normoalbuminuric, 33 microalbuminuric and 27 proteinuric) and their levels of proinflammatory cytokines (IL-6 and TNF α) were measured and correlated with albuminuria and glycosylated haemoglobin. RESULTS Urinary albumin excretion showed positive correlation with the levels of Interleukin-6 (r=0.711 P <0.001), as well as Tumour Necrosis Factor Alpha (r=0.591; P < 0.005) in the diabetics. The glycosylated haemoglobin had a positive correlation with Il-6 (r=0.792, P <0.001) and Urinary albumin excretion rate (r=0.685, P < 0.001) and mild positive correlation with TNF-α (r= 0.589, P <0.005). There was no such correlation observed among control subjects. CONCLUSION The study shows that pro inflammatory cytokines levels are elevated in early diabetic nephropathy and are independently associated with urinary albumin excretion thus it can be hypothesized that their local release play a role in the renal damage in the development of renal damage.
Authors and Affiliations
Arindam Ghosh, Aritri Bir
Keywords
Related Articles
- EP ID EP535852
- DOI 10.18410/jebmh/2018/174
- Views 68
- Downloads 0
COMPARISON OF DEXMEDETOMIDINE WITH FENTANYL IN ATTENUATION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND INTUBATION
BACKGROUND Direct laryngoscopy and endotracheal intubation elicits a haemodynamic response associated with increased heart rate and blood pressure. The aim of the study is to compare the efficacy of intravenous dexmedeto...
ULTRASOUND SCREENING OF THYROID GLAND AMONG A SECTION OF POPULATION IN CENTRAL KERALA
BACKGROUND Thyroid diseases are commonest endocrine disorders in India. Studies have shown that one in ten adults in India suffer from hypothyroidism. But it is often underdiagnosed and goes undetected for years. The pre...
EFFECTIVENESS OF CT IN DIAGNOSIS OF PROPTOSIS
BACKGROUND Orbit is a pyramidal shaped anatomical space bound by orbital bones whose apex is continued posteriorly as the optic canal and rectangular base opens into the face. Though a series of canal, fissures and foram...
ESTIMATION OF HEIGHT FROM THE LONG BONES OF LOWER LIMB AND FOOT DIMENSIONS IN SOUTH INDIAN POPULATION
Establishment of an identity is very much important in both civil and criminal cases. Stature is one of the criteria of personal identification. Many studies have shown that limbs exhibit consistent ratios relatives to t...
A STUDY ON NON-RESOLVING PNEUMONIA: ROLE OF FIBEROPTIC BRONCHOSCOPY AND CT-GUIDED BIOPSY
BACKGROUND Slow resolution of pneumonia despite treatment is a common clinical problem. Delay in diagnosis results in increased morbidity. We wanted to establish the aetiology, assess the associated risk factors and stud...