RELATIONSHIP OF PROINFLAMMATORY CYTOKINES WITH MICROALBUMINURIA IN PATIENTS OF TYPE 2 DIABETES MELLITUS- IMPLICATIONS IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 10
Abstract
BACKGROUND Type 2 diabetes mellitus is frequently associated with an increased inflammatory state. However, the relationship between of low grade inflammation and diabetic nephropathy still remains unclear with conflicting results. We therefore intended to analyse the inter-relationships between pro inflammatory cytokines and renal functions with respect to the glycemic status in type 2 diabetes mellitus patients. MATERIALS AND METHODS 89 type 2 Diabetes mellitus patients and 26 age matched healthy controls were studied (29 normoalbuminuric, 33 microalbuminuric and 27 proteinuric) and their levels of proinflammatory cytokines (IL-6 and TNF α) were measured and correlated with albuminuria and glycosylated haemoglobin. RESULTS Urinary albumin excretion showed positive correlation with the levels of Interleukin-6 (r=0.711 P <0.001), as well as Tumour Necrosis Factor Alpha (r=0.591; P < 0.005) in the diabetics. The glycosylated haemoglobin had a positive correlation with Il-6 (r=0.792, P <0.001) and Urinary albumin excretion rate (r=0.685, P < 0.001) and mild positive correlation with TNF-α (r= 0.589, P <0.005). There was no such correlation observed among control subjects. CONCLUSION The study shows that pro inflammatory cytokines levels are elevated in early diabetic nephropathy and are independently associated with urinary albumin excretion thus it can be hypothesized that their local release play a role in the renal damage in the development of renal damage.
Authors and Affiliations
Arindam Ghosh, Aritri Bir
Keywords
Related Articles
- EP ID EP535852
- DOI 10.18410/jebmh/2018/174
- Views 46
- Downloads 0
STUDY OF SERUM URIC ACID LEVEL IN DIABETES MELLITUS WITH SPECIAL REFERENCE TO CARDIOVASCULAR RISK FACTORS
BACKGROUND This study intends to assess the level of serum uric acid in Type 2 diabetes mellitus and to identify whether any association exists between age, sex, anthropometric measurements (BMI, WHR), hypertension, dysl...
ACUTE BILATERAL VIRAL NECROTIZING RETINITIS: AN UNCOMMON CASE REPORT
A 22 year old male with a history of high grade fever 2 days, diarrhea 3 times and vomiting 2 times presented with diminution of vision in right eye of 1 days duration. His best corrected visual acuity (BCVA) was countin...
EFFECT OF CATARACT SURGERY (PHACO AND MANUAL SMALL INCISION CATARACT SURGERY) ON THE CORNEAL ENDOTHELIUM- A COMPARATIVE STUDY
BACKGROUND The aim of the study is to compare the effect of phacoemulsification cataract surgery and manual small incision cataract surgery on the corneal endothelial cell count. MATERIALS AND METHODS A prospective study...
ASSESSMENT OF NEW TEACHING MODULE IN ORTHOPAEDICS
BACKGROUND The basic knowledge of musculoskeletal system is essential to the practice of orthopaedics at primary care level. This study is an effort at exploring a new teaching module for undergraduate orthopaedic studen...
A STUDY OF LIPID PROFILE IN ANEMIA PATIENTS- CASE-CONTROL STUDY IN INDIAN PATIENTS DONE IN THANJAVUR MEDICAL COLLEGE, TAMIL NADU
BACKGROUND Anaemia is a chronic nutritional health problem in India. Though there are plenty of causes for anaemia, iron deficiency anaemia is the most common cause of anaemia. As we all know, elevated serum lipids have...