A Comparative Study of Clinical Outcome of Clopidogrel and Prasugrel in Patients of Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention in Indian Settings
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 3
Abstract
Objective: The aim of this study is to see and compare the effect of two combinations of dual antiplatelet therapy (aspirin plus clopidogrel with aspirin plus prasugrel) that includes event rates of stent thrombosis, re-infarction, revascularization and bleeding in patient of acute coronary syndrome undergoing PCI. Method: 223 patients of ACS attending cardiology OPD and emergency department were enrolled. Subjects were recruited through emergency presenting with a primary diagnosis of Acute Coronary Syndrome, after obtaining clearance from ethical and research committee and written informed consent from the patients. Results: Though our study supports the idea of increased incidence in bleeding with prasugrel then clopidogrel group. This has also been validated by various studies that were carried in this regard (15,16). In our study we didn’t find any evidence of re-stenosis, re-infarction, Re-vascularization and mortality at 1,3,6,12 month follow up in both groups. Conclusion: Despite less number of patient in prasugrel group the number of major and minor bleeding events were higher as compared to clopidogrel group with more number of patients, it can’t be concluded with certainty that the complications can be high in prasugrel group. Although prasugrel a more potent antiplatelet drug as compared to clopidogrel ideally benefit should be more as per the previous studies but due to its cost, availability and lack of long term follow up clopidogrel can be still a preferred drug in these groups of patient.
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Dr Aditya
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