Case Series of Pyoderma Gangrenosum Successfully Managed with Biological Dressing
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
Introduction: The management of recalcitrant vasculitic ulcers of pyoderma gangrenosum (PG) still lacks an ideal challenging topical agent which promotes optimum healing with negligible side effects. Current scenario of management depends on steroids and other immunosuppressive agents which are more devastating than the disease itself. Conventional treatment such as relief of pressure, wound debridement, local dressing, antibiotic therapy, skin grafting, and supportive therapy are somewhat effective in the treatment of such non-healing wounds. Biological dressings are the ideal dressing for the management of chronic wounds. The newer biological dressings like collagen and growth factors, targets the specific defects in the chronic ulcer environment. Collagen is a natural biological skin substitute, easily available, ready to use, non-antigenic, and non-pyrogenic. Collagen induced healing involve all three phases of the natural wound-healing cascade. Collagen sheets are derived from tissues of bovine, avian, porcine and fish origin, which comprises type I and III collagen. Case Report: We have treated five cases of chronic non-healing leg ulcers of PG with oral dapsone and corticosteroids, in combination with topical wet collagen sheet dressings. In all patients of PG included in our study, the ulcers healed completely within duration of 8 to 10 weeks. Conclusion: This study is being presented to highlight the superior efficacy of biological dressings in chronic vasculitic ulcers of pyoderma gangrenosum.
Authors and Affiliations
Prakash D
Keywords
Related Articles
- EP ID EP525749
- DOI -
- Views 47
- Downloads 0
Use of Bone Turnover Markers and Minerals as Indicators of Low Bone Mineral Density in Premenopausal and Postmenopausal Women for Early Detection of Osteoporosis
Morbidity and mortality associated with osteoporosis continues to be high in India primarily due to late diagnosis. The aim of this study was to evaluate the difference in the levels of the bone turnover markers, oestrog...
Primary Pelvic Hydatid Cyst: A Rare Case Report
Hydatid disease is caused by a cyclo-zoonotic parasite echinococus granulosus. Humans are accidental intermediate hosts of echinococus. Commonly involved organ is the liver followed by lungs, kidney and musculoskeletal s...
Waldmann’s Disease: A Rare Form of Protein Losing Enteropathy
Waldmann’s disease or primary intestinal lymphangiectasia is a rare disorder characterised by loss of protein from gastrointestinal tract. We present a patient with left upper limb hemi hypertrophy and chylous ascites as...
Resistance Status of Malaria Vector An. sundaicus and An. subpictus to Insecticide and Detection of Genotype Resistance using Polymerase Chain Reaction (PCR) in Sungai Nyamuk Village, Sebatik Island, Nunukan District, North Kalimantan
Malaria remains as one of the serious health problems given priority by the Ministry of Health (MoH) of Indonesia. Vector resistance to insecticides is one of the problems in malaria vector control program in Indonesia....
Thyroid Hemiagenesis with Agenesis of Isthmus a Case Report
Thyroid gland is an endocrine gland being highly vascular, having two lobes which are connected by an isthmus. Gland is somewhat H shaped in appearance. Thyroid anomalies can be in the form of unilateral lobar agenesis....