A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND CLONIDINE IN EPIDURAL ANAESTHESIA WITH ROPIVACAINE FOR LOWER ABDOMINAL AND LOWER LIMB SURGERY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 11
Abstract
BACKGROUND Epidural anaesthesia using Inj. Ropivacaine results in an effective anaesthesia and postoperative analgesia and addition of adjuvants would be advantageous. Clonidine and dexmedetomidine are α2-agonists used as adjuvants in epidural anaesthesia. Aim of our study was to compare Inj. Dexmedetomidine and Inj. Clonidine added to epidural ropivacaine with respect haemodynamic parameters- heart rate, systolic blood pressure, diastolic blood pressure, motor blockade and sedations scores in patients undergoing lower abdominal and lower limb surgeries. MATERIALS AND METHODS This prospective, randomized, double blind study involved 60 patients of ASA-I, II who were categorized into two groups- GroupRD (n=30) received 1µ/kg Inj. Dexmedetomidine and Group-RC (n=30) received 1 µg/kg Inj. Clonidine. Patients in both groups received 17 ml of Inj. Ropivacaine epidurally. Patients were assessed for sensory block of T10 level, heart rate, systolic blood pressure and diastolic blood pressure, motor blockade using modified Bromage score and sedation score using Ramsay sedation scale. RESULTS Epidural anaesthesia using ropivacaine and adjuvants either clonidine or dexmedetomidine resulted in good sensory analgesia. Haemodynamic parameters with respect to heart rate, systolic blood pressure and diastolic blood pressure were similar between the two groups and were statistically not significant (p >0.05). Sedation scores and modified Bromage scores were statistically significant (p <0.05) for brief intervals of time. CONCLUSION Clonidine and Dexmedetomidine when used as adjuvants to epidural ropivacaine result in stable haemodynamics. Their sedation and motor blockade effects are comparable without significant adverse effects.
Authors and Affiliations
Olugumanu Srinivas Kumar, Pradeep Hosagaoudar, Murali Y. V. , Sreenivas Reddy M
Keywords
Related Articles
- EP ID EP538019
- DOI 10.18410/jebmh/2018/204
- Views 63
- Downloads 0
EVALUATION OF CASES OF PORTAL HYPERTENSION BY COLOUR DOPPLER AND ULTRASONOGRAPHY
BACKGROUND In adults, the normal portal venous pressure is 5-10 mmHg. Portal hypertension is defined as portal venous pressure of more than at least 5 mmHg greater than the pressure in the hepatic veins or inferior vena...
A CLINICAL AND SURGICAL STUDY OF INCISIONAL HERNIAS
BACKGROUND Incisions through the abdominal wall are based on anatomical principles. The intra-abdominal pressure is considerable and the surgeon aims at leaving the abdominal wall as strong as possible after operation, o...
STUDY OF PLATELET COUNT-SPLEEN DIAMETER RATIO AS A NON-INVASIVE PREDICTOR OF OESOPHAGEAL VARICES IN PATIENTS WITH CIRRHOSIS OF LIVER
BACKGROUND Most cirrhotic patients will develop oesophageal varices over their lifetime and the annual rate of oesophageal haemorrhage is 5 to 15%. Current guidelines recommend using Upper Gastrointestinal Endoscopy (UGI...
A RETROSPECTIVE STUDY OF OBSTETRIC OUTCOME IN TEENAGE PREGNANCY AND OLDER PREGNANCIES
BACKGROUND Younger age pregnancy of the group 18 years to 19 years is characterized by adverse maternal outcomes like anaemia, hypertension, low birth weight babies and intra uterine growth restriction. A comparative ret...
TRANSANAL DRAINAGE OF ANASTOMOTIC LEAK FOLLOWING LOW ANTERIOR RESECTION- A NOVEL TECHNIQUE
BACKGROUND Anastomotic leaks after low anterior resection following rectal cancer is the major cause for morbidity and mortality. Various techniques for the conservative management of localised abscesses have been report...