A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND CLONIDINE TO ATTENUATE HAEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND INTUBATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 19
Abstract
BACKGROUND Laryngoscopy and tracheal intubation after the induction of anaesthesia are nearly always associated with a sympathetic hyperactivity. To attenuate the pressor response various drugs have been tried, but these drugs were either partially effective or they produced undesirable effects. This study aims to compare the effects of Dexmedetomidine (0.5 µg/kg) and Clonidine (0.5 µg/kg) on haemodynamic responses to endotracheal intubation, effect on anaesthetic requirements and effect on sedation. MATERIALS AND METHODS In this prospective, randomised, clinical trial, 100 patients of either sex, aged 20 - 60 years of ASA grade I and II scheduled for elective surgeries under general anaesthesia were randomly divided into two groups Group D (Inj. Dexmedetomidine dose 0.5 μg/kg IV in 100 mL normal saline) and Group C (Inj. Clonidine dose 0.5 μg/kg IV in 100 mL normal saline). Haemodynamic parameters (HR, SBP, DBP, MAP, SpO2) were monitored continuously and recorded before the start of infusion, at the start of infusion, at 5 mins of start of infusion, at 10 mins of start of infusion, at intubation and then at 1, 3, 5 and 10 minutes after intubation. RESULTS Magnitude of increase in heart rate at intubation and 1 min after intubation was higher in Group C as compared to Group D and this was statistically significant. Group C had significant rise in SBP and DBP during intubation and at 1, 3, 5 and 10 mins after intubation as compared to Group D. Significant reduction in dose is required for induction in Group D than in Group C. CONCLUSION Dexmedetomidine significantly attenuated the sympathetic response of laryngoscopy and intubation as compared to clonidine.
Authors and Affiliations
Balwinder Kaur, Hardeep Bariar, Parmod Kumar, Sahil Garg, Charu Sharma, Lalit Kumar
Keywords
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- EP ID EP418280
- DOI 10.14260/jemds/2018/541
- Views 57
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