CORRELATION OF COAGULATION MARKERS WITH AXILLARY LYMPH NODE METASTASIS IN CARCINOMA BREAST
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 91
Abstract
BACKGROUND The relationship between malignancy and thrombosis is known for over 100 years. Thrombocytosis, an increase in fibrinogen and fibrin degradation products like D-dimer arise in factors V, VII, VIII, IX and XI levels and a decrease in antithrombin III are seen in cancer patients. Extracellular remodeling of fibrin is essential for angiogenesis in tumours and activation of intravascular fibrin formation and degradation has been shown to occur in the plasma of breast cancer patients. The objectives of this study are1. To correlate plasma level of coagulation markers (D-dimer) with clinico-pathological stage of carcinoma breast. 2. To assess role of coagulation markers (D-dimer) value as predictive markers of lymph node metastasis in breast cancer. 3. To assess changes in D-dimer values according to increasing (pathological) lymph node involvement. MATERIALS AND METHODS This study was conducted in the Department of Surgery in Dr. S. N. Medical College, Jodhpur, Rajasthan, India and included 25 patients admitted in surgery ward from January 2016 to June 2017 (Prospective study). HPE of breast specimen was done and pathological examination report were analysed with Plasma D-Dimer value. RESULTS There was statistically significant correlation between mean values of plasma D-Dimer and advancing stage of disease, tumour size, histological grade and lymphovascular invasion. CONCLUSION Plasma D-Dimer level is elevated in breast carcinoma, especially in those with advanced stage. Increased D-Dimer level is an important marker of clinical stage, lymphovascular invasion, lymph node involvement and tumour metastasis. So preoperative plasma D-Dimer may prove to be a safe, convenient and easily available predictive marker of advanced breast carcinoma.
Authors and Affiliations
Ganpat Singh Choudhary, Man Singh Bairwa, Amit Choudhary, Rishi Singodia
Keywords
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- EP ID EP278671
- DOI 10.14260/jemds/2017/1402
- Views 91
- Downloads 0
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