A Comparative Study of Efficacy and Safety of Non-fixed Combination of Dorzolamide/timolol and Latanoprost/Timolol in Open Angle Glaucoma or Ocular Hypertension
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 8
Abstract
Abstract:The Aim of this study was to compare the clinical efficacy and safety of non-fixed combination (NFC) of dorzolamide (2.0%)/timolol maleate (0.5%) versus NFC of latanoprost (0.005%)/timolol maleate (0.5%) regarding reduction of intra ocular pressure in patients with primary open angle glaucoma. This was a 12-week, randomized, open label, parallel group study with primary open angle glaucoma (IOP range: 24 – 36 mmhg), which included 40 subjects in dorzolamide/timolol group [dorzolamide (2.0%) instilled twice daily and timolol maleate (0.5%) twice daily]and 40 subjects in latanoprost/timolol group [latanoprost (0.005%) instilled once daily, timolol maleate (0.5%) twice daily]. IOP was measured at baseline, 4 and 12 weeks at 10 am. Adverse events were recorded at each visit. The difference in reduction of IOP in two treatment groups from baseline to 12 weeks was the main outcome measure. Mean IOP was similar at baseline for both groups. Absolute reduction in IOP from baseline to 12 weeks was 9.6 mmhg in dorzolamide/timolol group (P <0.001) and 9.7 mmhg in latanoprost/timolol group (P <0.001). No significant difference was found regarding reduction of IOP between the groups (P < 0.85). Both treatments were well tolerated. NFC of dorzolamide/timolol and latanoprost/timolol showed comparable efficacy in reducing IOP. They were also comparable regarding safety profile. Keywords: Glaucoma, Non-fixed combination therapy, dorzolamide/timolol, latanoprost/timolol.
Authors and Affiliations
Rabindranath Das, Pragnadyuti Mandal
Keywords
Related Articles
- EP ID EP397692
- DOI -
- Views 79
- Downloads 0
Impact of Leadership Styles on Work Related Stress among Nurses
Abstract: It is very vital for this profession to provide Nursing care and treatment with great quality and respond to client’s requirements. Leadership styles has a great role in professional task achievement, in this s...
Assess Spirituality and Spiritual Care in Nursing Practice in Public Hospital Lahore
Abstract: In the health sector, there is an emergent attention in spiritual care, which has resulted in more research around the topic spirituality and spiritual care. But, here is little research showing how nurse’s pro...
A Study on Litseamonopetala for Evaluation of Pharmacological Activities
Abstract: The aim of this study was to evaluate the cytotoxicity, thrombolytic, anthelmintic and antioxidant activity of mehanolic extract of Litseamonopetala(Family: Lauraceae) leaves in laboratory using in vitro method...
Alterations in glutamate metabolism in rat brain by tramadol analgesia during non-induction of pain
Abstract: The objective of this study was to evaluate the effects of tramadol, a centrally acting synthetic opioid analgesic, on glutamate metabolism, without inducing pain. Male adult Wistar rats weighing 150 ± 20 g wer...
Dependency of Acute Toxicity and Diuretic Activity upon the Chemical Structure in A 7-Substituted 8-Amino-3-Methylxanthines Row
Abstract: Derivatives of 7-substituted-8-amino-3-methylxanthines is a promising group of substances for synthesis and pharmacological screening in order to create diuretics, for pharmacological correction of the kidneys,...