A Study on Litseamonopetala for Evaluation of Pharmacological Activities
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 8
Abstract
Abstract: The aim of this study was to evaluate the cytotoxicity, thrombolytic, anthelmintic and antioxidant activity of mehanolic extract of Litseamonopetala(Family: Lauraceae) leaves in laboratory using in vitro methods. Cytotoxicity test was done by brine shrimp lethality bioassay where the extract concentration was 400, 200, 100, 50, 25, 12.5, 6.25, 3.125, 1.5625, 0.78125 (µg/ml). In vitro thrombolytic activity was performed by clot lysis method using extract concentration 2.5, 5, 10 and 20 (mg/mL) in saline water. Anthelmintic activity test was done by using adult earthworms where 10, 20, 40, 60, 80 (mg/ml) extract concentration were used. Finally antioxidant activity was determined by total phenolic content determination using Folin-Ciocalteu reagent. The crude extract of Litseamonopetalashowed cytotoxic activity against brine shrimp nauplii and LC50 value was 41.05(µg/ml) and the investigated thrombolytic activity in our research was 9.52,9.49, 13.64 and 17.50 % respectively as % of clot lysis. The paralysis time were at 76.75 min, 60min, 51.75 min, 44.5 min and 64.5 min and death were at 90.50min, 63.75min, 55.50min, 44.75min and 71min. respectively. The crude extract displayed significant antioxidant activity which was 20.75 (mg of GAE / gm) of extracts. The activities observed could be attributed to presence of some of the phytochemicals which have been related with cytotoxic, thrombolytic, anthelmintic and antioxidant property. Keywords: Litseamonopetala, cytotoxic, thrombolytic, anthelmintic and antioxidant activity.
Authors and Affiliations
Md. Shohel Hossain, Mohammad Tarek Aziz, Khondoker Md. Akter-uz-zaman Sumon, Md. Ibrahim . , Abida Sultana, NaneGopal Sarker, Palash Das, Md. Masudur Rahman
Keywords
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