A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF TAMSULOSIN AND SILODOSIN IN TREATMENT OF LOWER URINARY TRACT SYMPTOMS ASSOCIATED WITH BENIGN PROSTATIC HYPERPLASIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 2
Abstract
BACKGROUND Agents with a high degree of selectivity for α1A receptors have beneficial effects on the symptoms associated with benign prostatic hyperplasia (BPH) and less effect on blood pressure. The α1 antagonists generally preferred in the management of BPH are Tamsulosin and Silodosin because of their minimal hemodynamic adverse effects. There have been only few comparative studies between these two drugs. Therefore, this study was undertaken to compare efficacy of silodosin and tamsulosin in treatment of lower urinary tract symptoms (LUTS) associated with BPH. MATERIALS AND METHODS A total of 70 newly diagnosed patients suffering from LUTS associated with BPH were randomly divided into two groups with 35 patients in each group. Tamsulosin group received Tamsulosin 0.4 mg orally once daily for 12 weeks and Silodosin group received Silodosin 8 mg orally once daily for 12 weeks. Assessment of efficacy was done by assessing improvement in the International Prostate Symptom Score (IPSS), Urinary Flow Rate (Qmax) and assessment of Quality of Life (QOL) at base line, 4 weeks and 12 weeks. RESULTS The changes in IPSS total score, Qmax and QOL were significant within the groups but not between the groups CONCLUSION Both the drugs are equally effective in treatment of LUTS associated with BPH.
Authors and Affiliations
Amulya F. Yaraguppi, Ramesh H, Ravikumar Jadav
Keywords
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- EP ID EP553083
- DOI 10.14260/jemds/2019/32
- Views 58
- Downloads 0
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