A Comparative Study of Efficacy of 10% KOH, Tricholoracetic Acid (TCA) and 0.05% Tretinoin for the Treatment of Molluscum Contagiosum
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 4
Abstract
Abstract: Molluscum contagiosum is a common cutaneous infection seen in children and young adults. It is caused by the Molluscum contagiosum virus which is a DNA virus. Its mode of transmission is by contact with an infected person or fomites or autoinoculation. Although it is a self limiting condition, a decision may be made in favour of active therapy to prevent further spread, relieve symptoms, to prevent scarring and for cosmetic and social reasons. The current treatment modalities include physical destruction of the lesion by curettage, cryosurgery or manual expression and topical application of caustic agents such as trichloroacetic acid, cantharidin, silver nitrate etc. These therapeutic approaches have to be undertaken in a hospital setup and are not well tolerated by children owing to substantial pain and fear. In addition, these can also result in scarring and abscess formation. Topical application of 10% KOH solution and 0.05% Tretinoin cream are two relatively painless modalities that have been used with success in the treatment of Molluscum contagiosum. The objectives were to compares the efficacy and side effects of 10% KOH, TCA and 0.05% tretinoin cream in the treatment of Molluscum contagiosum. Sixty patients were randomly divided into 3 groups.The Group I have given 10% KOH solution to be applied at bed timeover molluscum lesions. The Group II has given 0.05% tretinoin cream to be applied at bed time over lesions. The Group III applied TCA in OPD. The assessment of response and side effects were performed weekly for 4 weeks. The results showed that the mean lesion count decreased from 22.39 to 10.75 with tretinoin, from 20.79 to 4.31 with KOH and from 20.49 to 4.1 with TCA at the end of 4 weeks. We found complete clearance of lesions in 8 (44.44%) patients with tretinoin, in 11 (50%) patients with 10% KOH and in 12(60%) with TCA. Minor side effects were seen in 17(85%) patients on TCA, 16 (72.72%) patients on KOH and 10 (55.56%) patients on tretinoin. The results of this study suggest that all three agents i.e.0.05% tretinoin cream, 10% KOH solution and TCA are equally effective in Molluscum contagiosum though TCA has a faster onset of action. However, TCA solution is associated with a higher incidence of side effects. Keywords: KOH, Tricholoracetic acid, Tretinoin, Molluscum contagiosum
Authors and Affiliations
Vippan Goyal, Ashwani Kumar Maheshwari, Shammi Goyal, Manharan Gill
Keywords
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