A comparative study of endoscopic findings, Rapid Urease Test and Conventional Histopathology in diagnosis of Helicobacter Pylori infection
Journal Title: Pathology Update: Tropical Journal of Pathology and Microbiology - Year 2017, Vol 3, Issue 3
Abstract
Background: Helicobacter pylori (H pylori) related gastritis is a major health ailment in developing nations. There is high morbidity and mortality ranging from chronic gastritis to gastric malignancies. Prevalence of H pylori infection varies markedly from country to country and in a country, region to region. Aim of the study: To evaluate the commonly available diagnostic methods, Rapid Urease Test (RUT) and conventional histopathology in diagnosis of H pylori gastritis and analyse the association of H Pylori with the development of gastrointestinal complications. Settings and design: Cross sectional prospective study conducted during the period of May 2012 to September 2014. Material and method: The study was carried out in a tertiary medical college hospital in southern India. Patients presenting with dyspeptic symptoms were subjected to endoscopy and investigated for H pylori infection through histopathological examination and RUT of biopsy specimen. Diagnosis of H pylori was made if one or both diagnostic test results were positive. Results: Out of 530 patients analyzed, diagnosis of H pylori was made in 329 patients (62.0%). There were significant statistical correlations of presence of endoscopic abnormalities and serious gastrointestinal complication (peptic ulcer and dysplasia/cancer) with H pylori infection. RUT had comparable predictive values to histopathology in diagnosis of H Pylori infection. Conclusion: H Pylori is implicated with significant morbidity and mortality due to associated gastrointestinal complications. Early and precise detection by multiple cost-effective methods, bearing good patient compliance and prompt treatment is essential for prevention of serious complications.
Authors and Affiliations
Shashikant Adlekha, Tandra Chadha
Keywords
Related Articles
- EP ID EP264179
- DOI 10.17511/jopm.2017.i3.02
- Views 163
- Downloads 0
The spectrum of neoplasms of uterine cervix and their clinicomorphological correlation in tertiary care center in dakshina Karnataka
Introduction: Cervical carcinoma is one of the leading causes of death among women worldwide. An estimated of 2,30,000 women die annually from cervical cancer, and almost 1,90,000 are from developing countries. It is con...
Histopathological study of thyroid lesions in a tertiary care center in coastal belt of South India
Introduction: Significant information regarding the lesions of thyroid can be obtained by histopatholological examination of the thyroidectomy specimens. Hence a scrupulous and methodical examination of the thyroidectomy...
Geographic mapping of head and neck cancers in Nanded, Maharashtra, India: A hospital based study
Background: Head and neck cancers are most common in developing countries. It is the most common cancer of males in India and fifth in females. India is classified as a lower middle income group country by World Bank. Na...
Primary squamous cell carcinoma of breast: A Rare Case Report
Primary squamous cell carcinoma (SCC) of breast is a pure epithelial type of metaplastic carcinoma accounting for less than 0.1% of all breast cancers. A 70 year female presented with left breast lump of 4 months duratio...
Resurgence of Diphtheria – A case report
Diphtheria is a highly infectious and one of the most common causes for childhood mortality. In developed countries, diphtheria has been completely eradicated with the introduction of effective immunization program. In d...