A Comparative Study of Hyperbilirubinemia, Elevated C-Reactive Protein and Leucocyte Count as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 4
Abstract
Background: Appendiceal perforation in patients with acute appendicitis may cause a variety of potentially life-threatening complications. Escherichia coli endotoxin has been shown to impact physiological bile flow in vivo. This had led to the theory that hyperbilirubinemia and elevated CRP in patients with appendicitis may have a predictive potential for the preoperative diagnosis of appendiceal perforation. Objectives: The aim of this retrospective study was to investigate the diagnostic value of hyperbilirubinemia and elevated CRP as a preoperative laboratory marker for appendiceal perforation in patients with acute appendicitis. Thus a new marker for appendiceal perforation would be welcomed. Thus, the need for the study is to conclude whether the Serum Bilirubin or CRP can be considered as a new laboratory marker to aid in the diagnosis of Appendicular Perforation. Materials and methods: All patients admitted with clinical diagnosis of "Acute Appendicitis" or "Appendicular Perforation" and undergoing surgery in General Surgery Dept in Tertiary Care Teaching Hospital were taken as Subjects for this study. The primary data for this study were the blood investigations of the patients. 200 patients with concerned consent and meeting the inclusion criteria were included in the study. The necessary clinical and lab details were obtained in a prewritten format. The intraoperative findings were noted and documented precisely. Upon completion of data collection the preoperative bilirubin levels of the perforated and uncomplicated groups wereOther clinical and lab parameters obtained during the study were compared between the two groups. All parameters were subjected to statistical analysis and evaluated critically. Results: A total of 200 patients participated in the study. Of the 200 patients studied 132 patients were males and 68 patients were females. The youngest patient was 13 years old and the oldest 64 years. Among all the patients operated with a diagnosis of Acute Appendicitis 92 were found to have a perforated appendix, and 108 were found to have a non-perforated appendix. It was observed that among 92 patients with perforated appendix 86 patients showed a raised CRP levels and 58 patients had a raised Bilirubin levels. However in case of non-perforated cases it was found that among the 108 cases 82 patients had a raised CRP levels and 36 patients showed raised bilirubin levels. Conclusion: Hence Logistic Regression technique revealed that the C- reactive protein and Hyperbilirubinemia can be used to predict the appendicular perforation preoperatively and that their roles are comparable and that there is no definitive advantage of one over the other for the same.
Authors and Affiliations
U. S. Parihar
Keywords
Related Articles
- EP ID EP552714
- DOI -
- Views 88
- Downloads 0
Suicides in Bikaner, Rajasthan Demographic profile and causative factors.
The natural end of every human life is death. Some people for various reasons end their own lives. This is called suicide. Recent suicides of farmers across country due to drought and crop failure has become a sensationa...
Relationship between ABO Blood Group and Periodontal Disease: A Clinical Study
Objectives: The purpose of the present study was to determine the association between periodontal diseases and ABO blood groups, particularly in relation to a specific geographic location, namely Kamrup District, Assam....
A Study to assess levels of Depression, Anxiety and Stress between First and Final year Medical students of Selected Medical College Karimnagar District, Telangana
Objective: To assess and compare the prevalence of Stress, Anxiety and Depression (by DASS scale) in MBBS students of selected Medical College of Karimnagar District of Telangana state. Study Design: Descriptive Cross se...
Changes in Electrolytes Level and ECG Parameters in Chronic Kidney Disease Patients Post Haemodialysis and the Correlation of Their Changes : A Cross-Sectional Study Done In Karwar, Karnataka
Background: Patients with chronic kidney disease undergoing maintenance haemodialysis have Electrocardiogram abnormalities. Aims & Objectives: To compare the serum electrolytes level and ECG parameters in chronic kidney...
Study of Clinical and Laboratory Profile in Alcoholic Liver Disease.
Background- Chronic alcohol abuse can result in a spectrum of liver injury that ranges from mild fatty infiltration to cirrhosis and hepatocellular carcinoma. Methods- Fifty patients presenting with alcoholic liver disea...