A Comparative Study of Injection Propofol Continuous Infusion and Bolus Doses for Maintenance of Anesthesia in Short Surgical Procedure
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 6
Abstract
Introduction: propofol is an intravenous anesthetic that is being used since years and it is most commonly used induction agent now a days.it has become very popular because of its characteristics of smooth induction and smooth recovery as well.in our study we studied the use of propofol during maintance of anesthesia and we compared two techniques of propofol administeration: continous infusion and bolus doses of propofol. Material and methods: This was an hospital based randomized control prospective study. After assessing patients and recorded all the vital parameters,patient was induced with iv propofol and in Group I, maintenance of anesthesia was achieved with an infusion of propofol at the dose of 100 μg/kg/min, while in Group II, maintenance of anesthesia was achieved with infusion in IB dose of 0.5 mg/kg on the need basis.Hemodynamic and other monitoring parameters were observed continuously and noted at an interval of 5 min during the operation.Intraoperative depth of sedation was measured by observers assessment of alertness and sedation scale. Score of 1 was considered to be the adequate depth of sedation while score 2 or more was considered to be inadequate depth. CI group patients with inadequate depth were excluded from the study. IB group with inadequate depth was given boluses dose of injection propofol 0.5 mg/kg.Patients were ventilated with 100% oxygen with Bains Circuit. After surgery was over in IB group, no additional dose was given while in continuous group infusion was stopped immediately. Result: There was no statistical significant differences among demographic parameters such as age, weight and sex. After 30 min of induction, there was a significant reduction of systolic blood pressure in both the groups and the statistically significant difference was there between GroupsI and II (P= 0.05). there was a significant reduction of DBP from the baseline, and statistically, significant difference was there between GroupsI andII (P=0.033). The mean dose of propofol was required more in CI as compared to IB. There was a statistically highly significant difference between both the group with respect to a dose of propofol (P= 0.001).71% of study subjects did not have any side effects. 14% had hypotension and 7% had bradycardia. Apnea was more in group II than group I subjects. Conclusion: In our study, we compared two commonly used methods of dosing regimens, i.e., IB and CI. Both regimens provided comparable hemodynamic stability, depth of sedation, the incidence of adverse effects and recovery time. CI was associated with higher dose requirement and hence higher cost while it was also found to be the more satisfactory mode of anesthesia for both surgeons and patients. Each mode has its own advantage and disadvantage, and hence the method of choice depends on anesthetist’s preference, availability of equipment and patients factors.
Authors and Affiliations
Veena Kachhwah, Deepti Agarwal, Krishna Kumar, Neeraj Narang Thakur
Keywords
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