A comparative study of intrathecal bupivacaine (3.5ml) with nalbuphine (0.6mg) and intrathecal bupivacaine (3.5ml) with nalbuphine (1.2mg) in lower abdominal surgeries
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 1
Abstract
Background: Various adjuvants including opioids, have been used with local anaesthetics in spinal anaesthesia to reduce complications as well as to increase peri and postoperative analgesia. Nalbuphine is a semi synthetic opioid with mixed antagonist and k agonist properties. Objective: To compare 0.6mg VS 1.2mg of intrathecal inj. Nalbuphine with inj. bupivacaine heavy 0.5% 3.5cc to establish the most effective dose for maximum postoperative analgesia in lower abdominal and lower limb surgeries. Methodology: Patients were randomly allocated to one of two groups. They received either nalbuphine 0.6 mg (group A) or nalbuphine 1.2 mg (group B) diluted upto 0.5ml with normal saline, mixed with 17.5 mg of hyperbaric bupivacaine 0.5% (3.5 ml). Patients basal vital parameters were recorded preoperatively using multiparameter monitor in the O.T. Results: The difference in mean duration of sensory blockade in both groups was found to be not significant (p>0.05). Mean duration of onset of motor blockade in Group A was 80.1 ± 11.01 seconds and in Group B it was 79.02 ± 7.98. The difference in mean duration in both groups was found to be not significant (p>0.05). Two segment regression time showed that mean duration in Group A was 62.2 ± 7.1 seconds and in Group B it was 76.9 ± 6.19. The difference in mean duration in both groups was found to be statistically highly significant (p<0.001). The difference in mean duration of post operative analgesia in both groups was found to be statistically highly significant (p<0.001). Conclusion: Intrathecal Nalbuphine (1.2mg) added to Intrathecal Bupivacaine 0.5% heavy (17.5mg) provides prolonged postoperative analgesia without increasing risk of side effects. Further studies are required to determine optimal dosage of intrathecal Nalbuphine.
Authors and Affiliations
Ramesh Babu, Prashanth Vadigeri, Mohan . , Lohit . , Sunil Kumar, Rajashekar Mudaraddi
Keywords
Related Articles
- EP ID EP559049
- DOI 10.26611/10151013
- Views 165
- Downloads 0
Comparison of the ultrasound guided technique versus the traditional blind anatomical landmark technique for the placement of central venous catheter in the internal jugular vein
Background: Internal jugular venous access is an essential part of patient management in many clinical settings. In the traditional technique, rates of major and minor complications can be as high as 10%. Ultrasound guid...
A comparative study between ondansetron, metoclopramide and placebo as a prophylactic medication to reduce postoperative nausea and vomiting
Background: Nausea and Vomiting are commonly faced post operative health illnesses among the patients undergoing surgery under general anesthesia. This study was planned to compare the effect of ondansetron, metocloprami...
Diagnostic value of different screening tests for predicting difficult intubation
Aims: The aim of current study was to compare the diagnostic value of different screening test in predicting difficult intubation. Settings and Design: Hospital based observational cross sectional study Methods and Mater...
Effect ofintra-articular fentanyl in combination with dexmedetomidine on postoperative analgesia after arthroscopy knee surgery
Background:Dexmedetomedine has been used as sole agent as well as adjuvant to another drug in several studies to enhance postoperative analgesia after knee arthroscopy with an increasedtime for the requirement of first r...
Comparison of effects of epidural fentanyl and dexmedetomidine on postoperative pain and gastrointestinal function following major abdominal surgeries
Background: Acute postoperative pain control needs considerable attention and use of epidural opioids like fentanyl is associated with significant side effects like postoperative ileus. Dexmedetomidine, α2 receptor agoni...