A comparative study of intrathecal bupivacaine (3.5ml) with nalbuphine (0.6mg) and intrathecal bupivacaine (3.5ml) with nalbuphine (1.2mg) in lower abdominal surgeries
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 1
Abstract
Background: Various adjuvants including opioids, have been used with local anaesthetics in spinal anaesthesia to reduce complications as well as to increase peri and postoperative analgesia. Nalbuphine is a semi synthetic opioid with mixed antagonist and k agonist properties. Objective: To compare 0.6mg VS 1.2mg of intrathecal inj. Nalbuphine with inj. bupivacaine heavy 0.5% 3.5cc to establish the most effective dose for maximum postoperative analgesia in lower abdominal and lower limb surgeries. Methodology: Patients were randomly allocated to one of two groups. They received either nalbuphine 0.6 mg (group A) or nalbuphine 1.2 mg (group B) diluted upto 0.5ml with normal saline, mixed with 17.5 mg of hyperbaric bupivacaine 0.5% (3.5 ml). Patients basal vital parameters were recorded preoperatively using multiparameter monitor in the O.T. Results: The difference in mean duration of sensory blockade in both groups was found to be not significant (p>0.05). Mean duration of onset of motor blockade in Group A was 80.1 ± 11.01 seconds and in Group B it was 79.02 ± 7.98. The difference in mean duration in both groups was found to be not significant (p>0.05). Two segment regression time showed that mean duration in Group A was 62.2 ± 7.1 seconds and in Group B it was 76.9 ± 6.19. The difference in mean duration in both groups was found to be statistically highly significant (p<0.001). The difference in mean duration of post operative analgesia in both groups was found to be statistically highly significant (p<0.001). Conclusion: Intrathecal Nalbuphine (1.2mg) added to Intrathecal Bupivacaine 0.5% heavy (17.5mg) provides prolonged postoperative analgesia without increasing risk of side effects. Further studies are required to determine optimal dosage of intrathecal Nalbuphine.
Authors and Affiliations
Ramesh Babu, Prashanth Vadigeri, Mohan . , Lohit . , Sunil Kumar, Rajashekar Mudaraddi
Keywords
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- EP ID EP559049
- DOI 10.26611/10151013
- Views 124
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