A comparative study of intravenous labetalol versus oral nifedipine in severe hypertension in pregnancy in a tertiary hospital ,Newdelhi
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Hypertensive disorders are the most common medical disorders encountered during pregnancy and are responsible for 15% of the maternal deaths in India.There is still controversy regarding choice of antihypertensive therapy in hypertensive emergencies in pregnancy. Currently Intravenous Hydralazine, oral Nifedipine and intravenous Labetalol are recommended for the treatment of severe hypertension in pregnancy.The objective of study was to compare the efficacy,safety, side-effects of intravenous labetalol and oral Nifedipine, mode of delivery in two groups, fetal outcome in patients receiving either Labetalol or Nifedipine in hypertensive emergency.A randomized control trial consisting of50 patientswas done over a period of one yearin Department of Obstetric and Gynaecology Dr.BabaSahebAmbedkar Hospital in Delhi. Efficacy of treatmentbasedside effects of drugs, number of doses required to attain target blood pressure,mode of delivery whether spontaneous or induced, normal or caesarean was noted in both groups. Fetal weight, maternal and neonatal outcomes were compared in each group. Our study provedboth drugs effectively control the blood pressure in severe hypertension in pregnancy. But Labetalol stood better than Nifedipine to decrease diastolic blood pressure and number of patients responding with first dose.But,further trials with larger sample size are needed to validate the results.
Authors and Affiliations
Chawla D, Khatri R, Minal . , Nayyer PS
Keywords
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- EP ID EP369250
- DOI 10.9790/0853-1703065659.
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