Role of Cystatin c and N-terminal pro-BNP in Hospitalized COPD patients with preserved left ventricular ejection fraction
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Preventive medicine and early disease detection is a gold standard medicine, Chronic obstructive pulmonary diseases (COPD) is independent risk factor for cardiovascular diseases,estimated to be third leading of disability and death by 2020.Cardiovascular diseases may be unrecognized when co-exist with COPD andportend poor prognosis. Since the two shared some clinical presentation, it’s a challenge for clinicians to accurately identify and differentiate patients with isolated COPD and COPD with left ventricular systolic dysfunction at early stages. Left ventricular systolic dysfunction in COPD patients is associated with poor prognosis. Cystatin c and NT-proBNP showed promising and emerged markers for early identification and ascertain prognosis of different diseases. The combined roles of the two biomarkers in COPD are subtle. We aim to find out combined role of cystatin c and NTproBNP inCOPD patients with preserved left ventricular ejection fraction.Methods: A retrospective study analyzed data of 1999 hospitalized COPD patients, categorized into Acute exacerbation COPD(AECOPD)n=1637(81.7%) and Stable COPD (SCOPD) n=362(18. 1%).Furthermore, COPD was categorized with reduced ejection fraction 91(10.3%) and preserved ejection fraction 795(89. 7%). Results: Both Cystatin c and NTproBNP increased with decreasedof left ventricular ejection fraction p-value <0.044, p <0 001 respectively. NT-proBNP found elevated in AECOPD (mean 1420±3419pg/mL) than SCOPD (1015±2514pg/mL),p<0.039. Cystatin c and NT-proBNP increasedwith duration of admission p<0.003, p<0.001 respectively.Conclusion:In this study, results shows that Cystatin c and NTproBNP which may be helpfully to the clinician even in limited resourced area to differentiate the two clinical conditions at early stages and to ascertain prognosis and treat accordingly to prevent further disease progression.
Authors and Affiliations
Dickson Athanasio Minja, Dedong Ma, Mengmeng Peng, AurelieKangoy Kasangye, Guanhua Zou, Chiku Mwimbo
Keywords
Related Articles
- EP ID EP423852
- DOI 10.9790/0853-1712068188.
- Views 31
- Downloads 0
Study of Prevalance of Impaired Glucose Tolerance and Diabetes Mellitus in PCOS Women (15 To 25)
.
A Spectrum of Metabolic Syndrome among Elderly Obese/ Overweight inpatients in a Rural Tertiary Care Hospital
Background: The metabolic syndrome(MetS), a cardiometabolic risk clustering is of public health significance. Diagnosing and managing the metabolic syndrome is beneficial for healthy ageing. There is little information i...
“A Prospective Cohort Study of 100 Consecutive Cases of Cholelithiasis Undergoing Laparoscopic Cholecystectomy In A Tertiary Care Ruralhospital.”
At times patient who has undergone Laparoscopic or Open Cholecystectomy may present with various Post-op Complications. Aims and Objective – To study the clinical, pathological and radiological parameters in patients pre...
Analysis of False Negative in Thyroid Swellings
Objectives: Is to find the accuracy rate of FNAC in Thyroid swelling and to analyse false negative FNAC Methods and Materials: A prospective study done for a period of 2 yrs in Tanjavur Medical College Hospital FNAC take...
Comparative Evaluation of Dentifrice Containing Herbal Extract With Triclosan/Polymer Containing PVM/MA in Its Ability To Control Plaque and Gingival Inflammation
Aim: To comparatively evaluate the dentifrice containing herbal agents and Triclosan/polymer containing PVM/MA in its ability to control Plaque and Gingival inflammation Materials and Methods: Subjects for the study were...