Role of Cystatin c and N-terminal pro-BNP in Hospitalized COPD patients with preserved left ventricular ejection fraction
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Preventive medicine and early disease detection is a gold standard medicine, Chronic obstructive pulmonary diseases (COPD) is independent risk factor for cardiovascular diseases,estimated to be third leading of disability and death by 2020.Cardiovascular diseases may be unrecognized when co-exist with COPD andportend poor prognosis. Since the two shared some clinical presentation, it’s a challenge for clinicians to accurately identify and differentiate patients with isolated COPD and COPD with left ventricular systolic dysfunction at early stages. Left ventricular systolic dysfunction in COPD patients is associated with poor prognosis. Cystatin c and NT-proBNP showed promising and emerged markers for early identification and ascertain prognosis of different diseases. The combined roles of the two biomarkers in COPD are subtle. We aim to find out combined role of cystatin c and NTproBNP inCOPD patients with preserved left ventricular ejection fraction.Methods: A retrospective study analyzed data of 1999 hospitalized COPD patients, categorized into Acute exacerbation COPD(AECOPD)n=1637(81.7%) and Stable COPD (SCOPD) n=362(18. 1%).Furthermore, COPD was categorized with reduced ejection fraction 91(10.3%) and preserved ejection fraction 795(89. 7%). Results: Both Cystatin c and NTproBNP increased with decreasedof left ventricular ejection fraction p-value <0.044, p <0 001 respectively. NT-proBNP found elevated in AECOPD (mean 1420±3419pg/mL) than SCOPD (1015±2514pg/mL),p<0.039. Cystatin c and NT-proBNP increasedwith duration of admission p<0.003, p<0.001 respectively.Conclusion:In this study, results shows that Cystatin c and NTproBNP which may be helpfully to the clinician even in limited resourced area to differentiate the two clinical conditions at early stages and to ascertain prognosis and treat accordingly to prevent further disease progression.
Authors and Affiliations
Dickson Athanasio Minja, Dedong Ma, Mengmeng Peng, AurelieKangoy Kasangye, Guanhua Zou, Chiku Mwimbo
Keywords
Related Articles
- EP ID EP423852
- DOI 10.9790/0853-1712068188.
- Views 49
- Downloads 0
To Evaluate the Prevalence of Primary Open Angle Glaucoma/ Ocular Hypertension In Patients Infected With Helicobacter Pylori
Aim: Helicobacter pylori (Gram negative bacilli), a commensal of gastrointestinal system is associated with many ocular manifestations. One of the associated links is proposed with glaucoma. Since the data on Indian popu...
A Study on Job Satisfaction of the Nurses Working At a Rural Medical College
This study was done on job satisfaction of the nurses working in Malda medical college and hospital, is a hospital based observational descriptive study, the design being cross sectional in nature. Total of 180 samples w...
Estimation of Thyroid Hormone Levels in Infertility: Study from a Tertiary Care Hospital, Andhra Pradesh.
Background: Prevalence of hypothyroidism among women in reproductive age group ranges from 6.2 to 11.4%. But there is variation in the prevalence in various parts of country in addition to high prevalence of sub clinical...
CT Evaluation of Temporal Bone Malignancies
Introduction: High Resolution Computed Tomography (HRCT), a modification of routine CT, provides a direct visual window in the temporal bone providing minute structural details. Purpose of the present study was to evalua...
Surgical Outcome of Mastoid Cavity Obliteration with Bone Dust versus Open Cavity in Canal Wall down Mastoidectomy - A Comparitive Study
Background: Chronic suppurative otitis media (CSOM) is a long standing infection of a part or whole of the middle ear cleft characterized by ear discharge and a permanent perforationˡ. The concept of mastoid obliteration...