Role of Cystatin c and N-terminal pro-BNP in Hospitalized COPD patients with preserved left ventricular ejection fraction
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Preventive medicine and early disease detection is a gold standard medicine, Chronic obstructive pulmonary diseases (COPD) is independent risk factor for cardiovascular diseases,estimated to be third leading of disability and death by 2020.Cardiovascular diseases may be unrecognized when co-exist with COPD andportend poor prognosis. Since the two shared some clinical presentation, it’s a challenge for clinicians to accurately identify and differentiate patients with isolated COPD and COPD with left ventricular systolic dysfunction at early stages. Left ventricular systolic dysfunction in COPD patients is associated with poor prognosis. Cystatin c and NT-proBNP showed promising and emerged markers for early identification and ascertain prognosis of different diseases. The combined roles of the two biomarkers in COPD are subtle. We aim to find out combined role of cystatin c and NTproBNP inCOPD patients with preserved left ventricular ejection fraction.Methods: A retrospective study analyzed data of 1999 hospitalized COPD patients, categorized into Acute exacerbation COPD(AECOPD)n=1637(81.7%) and Stable COPD (SCOPD) n=362(18. 1%).Furthermore, COPD was categorized with reduced ejection fraction 91(10.3%) and preserved ejection fraction 795(89. 7%). Results: Both Cystatin c and NTproBNP increased with decreasedof left ventricular ejection fraction p-value <0.044, p <0 001 respectively. NT-proBNP found elevated in AECOPD (mean 1420±3419pg/mL) than SCOPD (1015±2514pg/mL),p<0.039. Cystatin c and NT-proBNP increasedwith duration of admission p<0.003, p<0.001 respectively.Conclusion:In this study, results shows that Cystatin c and NTproBNP which may be helpfully to the clinician even in limited resourced area to differentiate the two clinical conditions at early stages and to ascertain prognosis and treat accordingly to prevent further disease progression.
Authors and Affiliations
Dickson Athanasio Minja, Dedong Ma, Mengmeng Peng, AurelieKangoy Kasangye, Guanhua Zou, Chiku Mwimbo
Keywords
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- EP ID EP423852
- DOI 10.9790/0853-1712068188.
- Views 65
- Downloads 0
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