Role of Cystatin c and N-terminal pro-BNP in Hospitalized COPD patients with preserved left ventricular ejection fraction
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Preventive medicine and early disease detection is a gold standard medicine, Chronic obstructive pulmonary diseases (COPD) is independent risk factor for cardiovascular diseases,estimated to be third leading of disability and death by 2020.Cardiovascular diseases may be unrecognized when co-exist with COPD andportend poor prognosis. Since the two shared some clinical presentation, it’s a challenge for clinicians to accurately identify and differentiate patients with isolated COPD and COPD with left ventricular systolic dysfunction at early stages. Left ventricular systolic dysfunction in COPD patients is associated with poor prognosis. Cystatin c and NT-proBNP showed promising and emerged markers for early identification and ascertain prognosis of different diseases. The combined roles of the two biomarkers in COPD are subtle. We aim to find out combined role of cystatin c and NTproBNP inCOPD patients with preserved left ventricular ejection fraction.Methods: A retrospective study analyzed data of 1999 hospitalized COPD patients, categorized into Acute exacerbation COPD(AECOPD)n=1637(81.7%) and Stable COPD (SCOPD) n=362(18. 1%).Furthermore, COPD was categorized with reduced ejection fraction 91(10.3%) and preserved ejection fraction 795(89. 7%). Results: Both Cystatin c and NTproBNP increased with decreasedof left ventricular ejection fraction p-value <0.044, p <0 001 respectively. NT-proBNP found elevated in AECOPD (mean 1420±3419pg/mL) than SCOPD (1015±2514pg/mL),p<0.039. Cystatin c and NT-proBNP increasedwith duration of admission p<0.003, p<0.001 respectively.Conclusion:In this study, results shows that Cystatin c and NTproBNP which may be helpfully to the clinician even in limited resourced area to differentiate the two clinical conditions at early stages and to ascertain prognosis and treat accordingly to prevent further disease progression.
Authors and Affiliations
Dickson Athanasio Minja, Dedong Ma, Mengmeng Peng, AurelieKangoy Kasangye, Guanhua Zou, Chiku Mwimbo
Keywords
Related Articles
- EP ID EP423852
- DOI 10.9790/0853-1712068188.
- Views 45
- Downloads 0
Study assessing life skills among school going adolescents in relation to personal variables
Adolescence is a period when various changes take place in their body, mind as well as in their behavior and habit forming. This brings the need for them to know dealing with these changes by Life Skill Education (LSE) b...
Institutional Experience with Electrosurgery Using Radiofrequency Inmanagement Of Idiopathic Epistaxis
This study is to find out the most common aetiology of epistaxis.Relation and correlation of nasal anatomical variations with respect to epistaxis. For earlyidentification of the cause and thereby management of idiopathi...
A Study on Fissural Anatomy of lungs in Adult Human Cadavers – Its Clinical Importance
The lungs are essential organs of respiration and are situated in the thoracic cavity on either side of the mediastinum. The arrangement of lung tissue into lobes by fissures facilitates the movements of the lobes in rel...
The Relationship between Adolescent Risk Behaviors and Family Structural and Process Factors: The Impact of Gender.
Family factors are important protective variables for adolescent development, risk behavior and outcome. Gender influences impact family interactions, rules and relationships. Adolescent cognitive, social and psycho emot...
Rationale and application of Nasolabial flap in the Management of Oral Submucous Fibrosis-A Case Series
Oral submucous fibrosis is an insidious chronic debilitating disease affecting the oral cavity, pharynx, and upper digestive tract and associated with restricted mouth opening. Its etiology is directly linked to betel nu...