Role of High Dose Methylprednisolone in Children With Steroid Resistant Nephrotic Syndrome
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Treatment of Steroid Resistant Nephrotic Syndrome(SRNS) imposes one of the most difficult problems on nephrologists. IntraVenous Methyl Prednisolone(IVMP) is considered as one of the treatments of choice for children with oral steroid resistant Nephrotic Syndrome. We reviewed the clinical outcome in children with SRNS not responding to Tacrolimus under intravenous methyl prednisolone treatment. A total of 32 children presented with SRNS during the period from January 2011 to December 2017. Mean age of patients was 7.9 (Range- 4 to 9 years). Renal Biopsy was done in 12 out of 32 children which showed Focal Segmental Glomerulosclerosis (FSGS) in 8 patients, 2 patients had Minimal Change Disease (MCD), another 2 had Diffuse Mesangial Proliferation (DMP). Treatment with IVMP along with oral prednisolone induced remission in 12 patients (37.5%), 4 patients had complete remission and 8 patients had partial remission. We conclude, the study shows that IV Methyl Prednisolone can be tried in patients not responding to Calcineurin inhibitors in SRNS patients.
Authors and Affiliations
DrP. Arun Prasath, DrR. Arul, DrA. Jegan, DrJ. Prem Giovanni, Dr. P. Krishnananth
Keywords
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- EP ID EP409194
- DOI 10.9790/0853-1711035557.
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