A prospective study of treatment of problematic infantile hemangiomas with propranolol and its outcome.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Aims: To study the use of propranolol as a single therapy in problematic infantile hemangioma and its outcome. Methods: Single institutional prospective study of patients of problematic infantile hemangioma treated with propranolol between January 2010 to December 2013. Assessment was done by change in colour , redness ,size and parental satisfaction. Outcome was defined in terms of complete, excellent, good/partial and no response. Results: 23 girls and 9 boys with infantile hemangioma were initiated treatment with propranolol at the mean age of 9.9 months(range 2-48 months) for a mean duration of 21 months(range 8-35 months). Head and neck was the most common site(75%). Complete/excellent response was seen in 20 patients(62.5%), good/partial response in 9(28.13%) and no response in 3 patients(9.38%). Rebound was seen in 2 patients. 4 patients showed increased sleepiness. Conclusions: Propranolol was safe, effective and should be the first line therapy in problematic hemangioma. Adjuvant therapy may still be needed in residual lesions and in partial response. Small superficial hemangioma showed excellent response. Hemangioma with deep components have high risk for rebound and probably need longer treatment
Authors and Affiliations
Janki Bisht, Rajarshi Kumar, Ruchirendu Sarkar, Nirup Biswas, Avijit Mitra, Akhilesh Kumar
Keywords
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- EP ID EP244438
- DOI 10.9790/0853-1610104046
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