A Comparative Study of Lipid Profile in HIV Infected and non Infected Subjects at a Tertiary Care Centre
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
Introduction: Metabolic derangements and body fat abnormalities are well known in HIV infection, both due to virus and to treatment. Various abnormalities in lipids are described in HIV. Increased triglyceride, low total cholesterol, low HDL, low LDL have been noted prior to treatment. With better medication and care, longevity of patients has increased resuting in worsening cardiovascular morbidity. It is hence mandatory to document the pretreatment lipid profile in HIV infected patients. Materials & Methods: A comparative cross sectional study of 50 treatment naïve HIV infected patients and 50 non infected controls were included in the study. Subjects were those attending the ART clinic, and HIV positivity was confirmed by NACO guidelines. Informed consent and ethical clearance and permission from KSACS were obtained. Patients with comorbidities likely to influence the lipid profile were excluded from the study. Detailed history, clinical examination data including anthropometry were entered in proforma. Lipid profile was tested in both groups. Results were computed and analysed using SPSS software. Results: There were significant differences in lipid profile between HIV infected and non infected groups. There was statistically significant lowering of total cholesterol LDL, HDL and elevation of triglycerides & VLDL in HIV infected. There was proportionate reduction in total cholesterol, LDL and HDL as CD4 count decreased. TG, VLDL increased as CD4 decreased. ( P <0.05). Conclusions: Pretreatment lipid abnormalities in lipid profile noted were lower TC, HDL & LDL and higher TG& VLDL. The abnormalities linearly correlated with CD4 counts.
Authors and Affiliations
Dr Radha . T. R
Keywords
Related Articles
- EP ID EP523780
- DOI -
- Views 84
- Downloads 0
Comparison of relapse rates after Escitalopram and Milnacipran continuation treatment in patients of major depression
Background: Depression is a chronic relapsing and recurring disorder. Relapse rate are about 50% in people with depression previously treated adequately by the antidepressant. Our study aims to compare the relapse rates...
Typical and Atypical manifestation of Dengue Fever: A Prospective Observational Study
Dengue is a major health problem in many parts of India and Jharkhand state has become one of the new endemic areas for dengue. Infection with dengue virus can cause a spectrum of clinical presentation, typical and atypi...
Toxic And Histopathological Changes of harmful Effect of Diclofenac Sodium on Some Loose Organs in Albino Rats for Twelve Weeks
The present investigation demonstrated the side effect of (I.M.) injection (75 mg/3 ml/ rat/ week) of diclofenac sodium for 12 week on the histological structure of some loose organs of adult rats. During the study no cl...
Spontaneous perforation of gallbladder and review of literature
Background: Spontaneous perforation of gall bladder is a rare entity with high mortality rate whenever there is diagnostic delay. Rupture of gallbladder in association with gallstones is infrequent and without gallstones...
Morphometry of Human Cadaveric Spleen: An Institutional Study in the Population of Odisha
Introduction: Spleen is an important secondary lymphoid organ. Now a day’s its immunological and haematological role in the body are well realised which enhances the clinical importance of spleen. As spleen shows a wide...