A Comparative Study of Preoperative Ketamine and MgSO4 Nebulisation for Incidence of Post Operative Sore Throat after Endotracheal Intubation
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Postoperative period consists of many complications of which sore throat (ST) has an incidence of 21- 65%, which is a minor but valid reason for dissatisfaction and morbidity among patient. Aims and Objective - To compare incidence of sore throat after nebulising preoperatively with MgSO4 and ketamine, in post operative period upto 24hours. Material and Methods: One hundred fifty patients preoperatively assessed with ASA grade I-II, age (20-50years), females, undergoing laparoscopic cholecystectomy under general anaesthesia were enrolled. Patients were randomised into 3 groups; group MgSO4 (GM) nebulised with 3ml of 225mg isotonic MgSO4, group ketamine (GK) nebulised with 3ml containing 50mg ketamine and group saline (GS) nebulised with 3ml normal saline, for 10 minutes. General anaesthesia was induced 5minutes after nebulisation. Haemodynamic monitoring was done during nebulisation and induction. ST monitoring was done in recovery room at 2,4,8,12 and 24hours post extubation. It was graded 0-III based on the severity. Results- The incidence of ST was 37.3% (56/150); 60% in GS (30/50), 30% in GM (15/50), 22% in GK (11/50) (p<0.05 for both GK and GM on comparing with GS), least with GK but insignificant on comparison with GM (p=0.37). Haemodynamic response to laryngoscopy was significantly (p<0.05) attenuated in GK. Discussion: GK and GM had significantly reduced incidence of ST after nebulisation on comparison with control group. Among GK and GM incidence was least with GK, but was statistically insignificant. Haemodynamic attenuation in response to intubation was observed in GK. Conclusion: Incidence of ST was significantly less with ketamine and MgSO4 nebulisation.
Authors and Affiliations
Shalini Jain, Swapnil Kumar Barasker
Keywords
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