Prevalence of Elevated Anti-Thyroid Peroxidase Antibodies in Subclinical Hypothyroidism
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Autoimmune thyroiditis is a common cause of subclinical hypothyroidism (SCH). The progression of SCH to overt hypothyroidism depends on multiple factors of which elevated thyroid peroxidase antibody (anti-TPO) levels is one of the risk factors. There are sparse data on the prevalence of anti-TPO among Indian patients with SCH. So the aim of the present study was to determine the prevalence of anti-TPO positivity in SCH. Material and Methods: We estimated anti-TPO levels in 215 patients of SCH between 18 to 60 years. Anti-TPO measurement was done by chemiluminescence method and a value of > 18 Iu/ml was considered as positive. Results: The mean TSH value was 9.08 ± 2.63 μU/ml. The prevalence of anti-TPO antibodies in SCH was 49.7%. The TSH was significantly higher in anti-TPO positive group. The anti-TPO prevalence was significantly higher with TSH ≥8μU/ml. Conclusion: There is a high prevalence of elevated anti-TPO in SCH patients which suggests an autoimmune aetiology. Since the subclinical hypothyroid patients with elevated anti- TPO titre are likely to develop overt hypothyroidism over a period of time, regular follow-up or initiation of replacement with levothyroxine is recommended.
Authors and Affiliations
Atluri Sridevi, Boppana Rakesh, Goel Amit, Yalamanchi Aiswarya, Biswas Anupam, Shivaprasad Channabasappa
Keywords
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