Immunohistochemical Staining by TTF-1 and P63 Markers for Typing of Non Small Cell Lung Carcinomas: A Three Year Study of A Tertiary Care Health Centre
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Studies have shown that selection of therapies such as vascular endothelial growth receptor (VEGR) and epithelial growth factor receptor (EGFR) inhibitors may depend on the correct differentiation of squamous cell carcinoma (SCC) versus adenocarcinoma (ADC). This study was done to evaluate role of thyroid transcription factor- 1(TTF-1) and P63 markers in differentiating SCC and ADC in lung mass biopsies. Material and methods: This study was conducted over a period of 2 years from October 2015 to December 2017. Total 52 cases of non-small cell carcinomas (NSCLC) including ADC and SCC were included. IHC staining for thyroid transcription factor-1 (TTF-1) and P63 were carried out for all the cases along with routine histopathological examination of tumour. Results: Out of total 52 cases, 16 cases were diagnosed as ADC, 22 cases as (SCC), 12 cases as NSCLC and 2 cases as papillary adenocarcinoma on histopathogy. All the 16 cases of ADC and 2 cases of papillary adenocarcinoma were positive for TTF-1, all the 22 cases of SCC were positive for P63 and out of 12 cases as NSCLC, 5 cases were positive for TTF-1 and 7 were positive for P63. None of the case showed simultaneous positivity for both IHC markers. Conclusion: SCC constituted 55.8% while ADC constituted for 44.2% cases. All the SCCs showed P63 positivity while All the ADCs showed TTF-1 positivity. Hence it can be concluded that TTF-1 and P63 are reliable IHC markers for further sub typing of NSCLC.
Authors and Affiliations
Amit Varma, Rashmi Patidar, Shilpi Dosi, Garima Malpani, Kamal Malukani, Priyanka Kiyawat Jain
Keywords
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