Evaluation of Efficacy of Ceftriaxone and Traditional Therapy of Ampicillin and Chloramphenicol in Treating Paediatric Patients with Bacterial Meningitis: A Comparative Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 4
Abstract
Introduction: One of the medical emergencies in paediatric patients which manifests as meningeal inflammation in response to bacterial infections is bacterial meningitis. Among paediatric patients, a lot of variation exists in relation to various clinical manifestations of bacterial meningitis. These also show considerable variations in terms of age and duration of the pathology. Hence; we conducted the present study to comparatively evaluate the effectiveness of ceftriaxone and traditional therapy of ampicillin and chloramphenicol in treating paediatric patients with bacterial meningitis. Material and methods: The present study was conducted in the department of paediatrics of the medical institute and included assessment of 40 paediatric patients that were suffering from meningitis. All the patients were divided randomly into two study groups with 20 patients in each group. First group included patients who were on Ceftriaxone therapy while the other group included patients who were on traditional therapy. All antibiotics were given intravenously. Ceftriaxone(50 mg/kg) was given every 12 h. In the traditional therapy group, those patients over 1 month of age initially received Ampicillin (200 to 400 mg/kg per day) and Chloramphenicol (75 mg/kg per day). Both drugs were given every 6h. Determination of complete blood count, prothrombin time, partial thromboplastin time, electrolytes, creatinine, urinalysis, bilirubin, serum glutamic pyruvic transaminase, and alkaline phosphatase was done before enrollment in the study, every 4days during therapy, and at the completion of the study.CSF bactericidal activity, CSF glucose and CSF proteins concentrations were determined. All the results were analyzed by SPSS software. Results:Total of 40 paediatric patients were enrolled in the present study. The mean age of the patients was 6.8 years. Non-significant results were obtained while comparing the mean CSF findings in between patients under different treatment therapies at initial time of assessment. In patients undergoing Ceftriaxone therapy, the mean percentage of poly-morphonuclear (PMN) leukocytes were 81 while in patients undergoing traditional therapy was found to be 80 after 24 hours of therapy. Mean CSF glucose concentration and mean CSF protein concentrations in patients undergoing Ceftriaxone therapy were 35 and 292 mg/dl respectively after 24 hours of therapy. Non-significant results were obtained while comparing the mean CSF findings in between patients under different treatment therapies after 24 hours of assessment. Conclusion: For treating paediatric patients with bacterial meningitis, ceftriaxone appears to be a safe and effective drug
Authors and Affiliations
Rattan Singh Bamal, Manu B, Princy B, Beena B
Keywords
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