A Comparative Study of Toxicities during Treatment With IMRT Versus 3DCRT in Locoregionally Advanced Head and Neck Carcinoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Context: Head and neck cancers represent a significant treatment challenge because the disease is located within an anatomical area that contains several critical tissues. With development of modern radiotherapy techniques, precise delivery of adequate dose of radiation to the tumor while sparing organs at risk has become possible. Aims: The present retrospective study was done to compare toxicity profile of IMRT versus 3DCRT in locally advanced head and neck cancer. Methods and Material: A total of 150 patients of histologically confirmed stage III to IVB squamous cell carcinoma of the oral cavity and oropharynx of either sex were evaluated in the study from July 2015 to June 2016; 58 in IMRT group and 92 in 3DCRT group. All patients received 70 Gy in 35 fractions with 2 Gy per fraction in both groups with 6MV photon beam concurrent with weekly cisplatin 30 mg/m2 . Results: At median follow-up of 18 months (range, 12 to 24 months), 3D-CRT group demonstrated significantly more acute toxic effects compared with the IMRT group. Significantly higher grade III or worse acute mucositis, dysphagia, acute and late xerostomia occurred in 57.6%, 84.8%, 71.7% & 63% of patients in 3DCRT group compared with 39.7%, 56.9%, 39.7% & 20.7% of patients in IMRT group (P-value 0.23, <0.001, <0.001 and <0.001 respectively). Conclusions: IMRT is associated with decreased early and late toxicities as compared to 3DCRT. It offers better normal tissue sparing, hence better quality of life.
Authors and Affiliations
Ajay Singh Choudhary, Rameshwaram Sharma, Kartick Rastogi, Kampra Gupta, Shivani Gupta, Sushil Kumar
Keywords
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- EP ID EP238805
- DOI 10.9790/0853-1611066669
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