A Comparative Study of two Fractionations Schedule of Palliative Radiation Therapy in Metastatic Brain Tumour
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Background: Management of Brain Metastases is a significant health care problem and is most common intracranial malignancy in adults. Whole brain radiotherapy (WBRT) is a mainstay of treatment. However, there is need to develop fractionation schedules, but total dose still remains dilemma. This prospective study aims to determine treatment outcome and prognostic factors by making comparison of long-course and short-course WBRT schedules. Materials and Methods: Sixty patients presented with symptomatic brain metastases previously untreated with WBRT were randomized in two arms containing 30 patients. Arm A treated with 30 Gy, 3 Gy/fraction (fr.), 10 fr. and arm B 20 Gy, 4 Gy /fr. (5fr.). All patients were assessed during WBRT and after completion of WBRT. Results: At 6 month of completion of WBRT objective response rate complete and partial (CR+PR) was 36.6% in arm A and 40% in arm B (p=0.72). WBRT regimen was not associated with survival (p=0.79). On multivariate analysis, age ≤ 65 years (p < 0.05), Karnofsky performance score (KPS) ≥ 70 (vs <70, p < 0.01), no extra-cranial metastases (p < 0.01) were significantly associated with improved survival. Conclusions: This study suggests that two fractionation schedules showed comparable results. Therefore, short-course WBRT may be used as an effective option in favor of small treatment time and convenient for patients.
Authors and Affiliations
Dr Shankar Lal Jakhar
Keywords
Related Articles
- EP ID EP508128
- DOI -
- Views 63
- Downloads 0
Gleason’s Grading of Carcinoma Prostate with PSA Correlation
Introduction: Serum PSA levels have been linked directly to a number of important prognosticators in the prostate gland including histologic grade. The present study has been undertaken on cases of carcinoma prostate, wh...
Adverse Reactions Associated with Single Donor Plateletpheresis Procedures in tertiary care centre at M.Y. Hospital, Indore
Background: Plateletpheresis is a procedure where the whole blood is processed from a donor and the platelets are separated and the remaining blood components are returned back to the donor. Adverse reactions of variable...
A Retrospective Study of ENT Foreign Bodies in 50 patients at a Tertiary Care Hospital in Navi Mumbai
Ear, nose and throat (ENT) foreign bodies (FBs) are common occurrences, particularly among children. The proper recognition, study, and management of FBs are required to prevent complications. Their consequences are grea...
Alexia without Agraphia Following an Ischaemic Stroke in a 70 Year Old Nigerian African
Pure alexia is an acquired reading disorder, in previously literate subjects who show correct writing (spontaneously or on dictation) and normal oral spelling in the absence of apraxia, dementia or visual agnosia. It is...
Ergonomics Solutions in Dental Practice
Increased modernization and immense use of technology in dental practice has exposed dentists to high risk of poor postural habits thus leading to high risk of musculoskeletal disorders like low back pain, tennis elbow a...