A comparative study of two marketed preparations of Vitamin D for safety and efficacy in Vitamin D deficient children
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Aim and Objectives: The present study was undertaken to compare the safety and efficacy of two Vitamin D syrups in normalizing various biochemical markers of Vitamin D deficiency in children. Method: 79 children of either sex, aged between 8 to 15 years were enrolled in the study. They were divided into two groups to receive either one of the two marketed formulations of Vitamin D3. 36 patients were treated with Uprise D3 [Syrup (A)] and 43 patients were treated with Deksel nano syrup (B). Both formulations containing 60,000 IU of Cholecalciferol were administered once a week for 10 weeks. The change in 25(OH) D levels from baseline was recorded at 6 weeks and 12 weeks. Results: Both the formulations have shown a significant rise in 25(OH) D levels but the rise with Syrup B was significantly higher than that seen with Syrup A over baseline, at week 6 and week 12. Treatment with either of the formulations was able to reduce the elevated alkaline phosphatase levels both at 6 and 12 weeks. But in neither of the case reduction from the baseline was significant. Serum calcium and serum phosphorus levels remained unaltered after either of the treatment, both at 6 and 12 weeks. Significant reduction in elevated parathyroid hormone levels was seen only with Deksel nano syrup. This was observed as early as 6 weeks of initiating treatment. Conclusion: Deksel nano syrup is a better formulation as it was shown to produce consistently higher rise in 25(OH) D levels. The formulation also demonstrated a trend towards normalization of elevated parathyroid hormone levels.
Authors and Affiliations
Dr Savita Khadse
Keywords
Related Articles
- EP ID EP505462
- DOI -
- Views 61
- Downloads 0
Complete Penile Disassembly for Epispadias Repair in Isolated Epispadias in a Postpubertal Patient: A Case Report
Epispadias is a rare congenital malformation of the male or female urogenital apparatus that consists of a defect of the dorsal wall of the urethra. The extent of the defect can vary from a mild glandular defect to compl...
Serum Vitamin D Levels In Type 2 Diabetes Mellitus - A Missing Link
Type 2 diabetes, a significant global health care problem is the fifth leading cause of death and also a major cause of significant morbidity. Although our current methods of treating type 2 DM and its complications are...
Effects of Nesiritide in Patients with Acute Decompensated Heart Failure – A Review
Acute decompensated heart failure is a major health problem that is associated with several million hospitalizations worldwide each year. [1] In such patients, the predominant symptoms are dyspnea and fatigue which are a...
Endoscopic Treatment of Chronic Venous Insufficiency by Interrupting Below Knee Perforating Veins: A Prospective Study
Chronic venous insufficiency (CVI) is a long-term disabling problem. The prevalence of venous ulceration due to chronic venous insufficiency has been estimated to be approximately 0.1 to 0.3%.1 In addition for each patie...
Comparative Assessment of Thoracic Epidural and General Anaesthesia in Modified Radical Mastectomy
A modified radical mastectomy is a technique in which the whole breast is removed, including the skin, areola, nipple, and most axillary lymph nodes; the pectoralis major muscle is spared. The study is conducted in Shri...