Levels of Upper Limit of Oxidative Stress Markers During Normal Pregnancy And Pre-Eclampsia
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 1
Abstract
Background: The reactive oxygen species (ROS) are involved in multiple reproductive processes – maturation of oocyte, fertilization, development of embryo, pregnancy and parturition. However, the optimal levels and interplay of oxidants and antioxidants is crucial for a positive pregnancy outcome. Pregnancy induced hypertension (PIH) is shown to have defective trophoblast invasion leading to high pressures in utero-placental circulation; thus this stress imposed on placenta may disturb the oxidantantioxidant balance. Aim: the purpose of this study was to assess the oxidative stress during uncomplicated pregnancy and pregnancy associated with hypertension in primi-gravida women. Materials And Methods: a total of 90 women were enrolled and divided into 3 groups. Group 1: Healthy non-pregnant women (n=30), Group 2: Normotensive primi-gravida women (n=30) and Group 3: Preeclamptic primi-gravida women (n=30). Blood samples were analyzed for levels of malondialdehyde (MDA), superoxide dismutase (SOD), total anti-oxidant capacity (TAC) and uric acid using appropriate biochemical methods. ANOVA was used for assessing the difference between the groups and statistical significance was fixed at p<0.05. Results: In the present study, levels of MDA, SOD and uric acid were significantly increased in pregnant compared to non-pregnant women and to a greater extent in pre-eclampsia women compared to normal pregnant women.TAC levels were significantly decreased in pregnant when compared to non-pregnant and much more decreased in pre-eclampsia women compared to normal pregnant women. Conclusion: high pressures in feto-placental circulation can lead to increased elaboration of oxidative radicals which may cause oxidative damage to placenta and other organs.
Authors and Affiliations
Usha Rani D
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