A Comparative Study on Hematological Inflammation Markers in Acne Vulgaris
Journal Title: International Blood Research & Reviews - Year 2015, Vol 4, Issue 4
Abstract
Aim: The literature does not include sufficient data on the hematological inflammation markers in acne vulgaris. The present study aimed to investigate potential of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as inflammatory markers in acne vulgaris. Study Design: This is a a case-control, comparative clinical study conducted with the approval of ethical review board. Place and Duration of Study: Department of Dermatology between March 2015 and July 2015. Methodology: The study included 45 moderate/severe acne patients and 30 age- and sex-matched controls. Demographic data, medical history were recorded. Laboratory parameters, including total leucocyte, neutrophil, lymphocyte, platelet counts, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume were retrospectively evaluated before treatment, and after 3-months of oral isotretinoin treatment. Parameters of the patient group (pre-treatment) and the control group, additionally pre-treatment and post-treatment parameters of the patient group were compared. Results: The mean total leucocyte count (P < 0.001), neutrophil count (P < 0.001), and neutrophil/lymphocyte ratio (P = 0.047) were significantly higher, and mean platelet volume (P < 0.001) was significantly lower in the patient group (pre-treatment) compared to the control group. Additionally, the mean post-treatment leucocyte count (P = 0.001), neutrophil count (P < 0.001), and neutrophil/lymphocyte ratio (P < 0.001) were significantly lower compared to pre-treatment parameters. Conclusion: Acne vulgaris is associated with systemic inflammation, and isotretinoin treatment has systemic anti-inflammatory effects. Especially, neutrophil/lymphocyte ratio is indicative of systemic inflammation in acne, and may be used as a follow-up marker during treatment.
Authors and Affiliations
Nilay Duman, Erol Uzunali, Vildan Manav
Keywords
Related Articles
- EP ID EP242617
- DOI 10.9734/IBRR/2015/21905
- Views 139
- Downloads 0
Myoglobin Status in Stable Patients with Chronic Kidney Disease
Aim: To measure serum myoglobin concentration in stable patients with chronic kidney disease (CKD) who had not commenced hemodialysis and determine its relationship with cardiovascular risk factors. Study Design: Cross-s...
Erythropoietic and Bone Marrow Stimulating Activity of Terminalia catappa Extract: Possible Role of Nitric Oxide Signaling
Aims: We assessed the capacity and mechanism of Terminalia catappa (TC) to induce erythropoiesis in vivo in phenylhydrazine- induced anemic mice. Place and Duration of Study: Sample: This study was carried out at Departm...
Bendamustine for Relapsed and Refractory Hodgkin Lymphomas: Four Cases and a Review of the Literature
Aims: The management of relapsed/refractory Hodgkin lymphoma is challenging and new choices are needed. Brentuximab vedotin and bendamustine are two effective drugs in these cases. The aim of this study is to present the...
Sero-prevalence of Anti- HCV among Yemenis Blood Donors Attending National Blood Transfusion and Research Centre in Sana'a: Yemen
Aim: To determine the current sero-prevalence of HCV among blood donors in Sana'a city: Yemen. Study Design: A descriptive cross sectional study. Place and Duration of Study: This study was conducted on 3606 blood donors...
Molecular Detection of Hepatitis C Virus (HCV) by Conventional One-step RT-PCR Coupled with Nested PCR
Aims: HCV causes both acute and chronic infections and can be easily transmitted through contaminated blood or other body fluids. The present study deals with the molecular detection of HCV with help of one-step RT-PCR a...