A Comparative Study on Safety, Efficacy, and Cost of Glipizide versus Glimepiride as an Add-On Therapy to Metformin
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Background: Diabetes Mellitus (DM) is associated with abnormalities in carbohydrate, fat, and protein metabolism. Pharmacoeconomic studies are pertinent to the decision-making process when trying to balance the costs of specific alternatives. Objective: To assess and compare the safety, efficacy, and cost of Glimepiride 2mg Vs Glipizide 5mg as an addon therapy in patients receiving Metformin 500mg. Method: A prospective comparative study was conducted for a period of 6 months on T2DM patients, subjects were recruited and grouped into 2 categories i.e. Group-A (metformin 500mg + glimepiride 2mg) and Group-B (metformin 500 mg + Glipizide 5mg). Efficacy of both treatments was assessed by using blood sugar levels data. The safety profile was assessed based on ADRs produced. Cost analysis was performed by using cost-effective analysis. Results: The % of reduction achieves in both groups (‘A’ Vs ‘B’) from first follow up to final follow up was FBS 14.3% (17.4 Vs 14.9), PBS 13.7% (27.18 Vs 23.6) and RBS 29.9% (25.13 Vs 17.6). Based on the ICER (Incremental cost-effective ratio) formula, to achieve the Group A effectiveness, Group B requires more amount of 84 INR (FBS), 58.8 INR (PBS) and 27.9 INR (RBS) than the Metformin 500mg + Glimepiride 2mg. Among the 21 ADRs reported 10 were Metformin with Glimepiride and 11 were Metformin with Glipizide. Conclusion: We conclude that the Glimepiride 2mg as add-on therapy with Metformin 500mg is little beneficial than Glipizide 5mg in terms of efficacy and cost. In terms of safety, both drugs are having similar safety profiles..
Authors and Affiliations
Kandavalli Sridevi1, Meda Venkata Subbaiah2 ,, S Sai Dath3 ,, Stephy Johnson3 ,, P Sunil Kumar3
Keywords
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- EP ID EP365276
- DOI 10.9790/0853-1702152429
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