Mast Cells in Surgically Resected Appendices
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background The vermiform appendix is the most common intra-abdominal organ subjected to frequent surgical intervention and resection. Appendicitis is the inflammation of appendix. It is usually a disease of the young, with 40% of cases occurring between the ages of 10 and 29 years. Appendicitis is the most common intra-abdominal condition requiring many times emergency surgery. The pathogenesis of appendicitis remains poorly understood. Mast cells are known to be effector cells in various inflammatory reactions but their role in appendicitis is unclear. Objectives 1. To find out the correlation between the histological findings and number of mast cells in appendicitis. 2. To evaluate the role of mast cells and their number in the pathogenesis of appendicitis. 3. To find out whether there is any association between specific age group and number of mast cells. Material and Methods The study was conducted on 200 surgically resected specimens of appendices received in the department of pathology, Govt. Medical College, Patiala. The appendix specimens were kept in 10% formalin overnight for fixation. After processing, two sections of 5-micron thickness were cut from the paraffin block. One of the sections was stained with 1% aqueous toluidine blue (Stain for the mast cell) and the other with routine haematoxylin and eosin (H&E) and examined under light microscope.
Authors and Affiliations
Dr. Amitoj Sandhu, Dr R. K. Kundal, Dr Ashwini Kumar, Dr Ninder, Dr Sankalp Sancheti, Dr Ramanpreet Kaur
Keywords
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- EP ID EP466991
- DOI 10.9790/0853-1802050107.
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