A comparative study on serum high sensitivity C-reactive protein and serum Creatinine Kinase (Total-CK) in acute myocardial infarction
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 12
Abstract
Introduction: C - reactive protein is a substance that is present in the sera of acutely ill patients and that is able to bind to somatic C-polysaccharide on the cell wall of streptococcus pneumonia. Development of assays capable of accurate measurement of CRP with concentration as low as 0.5mg/L are referred to as High-Sensitivity CRP (hs-CRP) assays. Serum Creatinine Kinase (Total-CK) is an enzyme expressed by various tissues including Cardiac tissue and can be easily measured in the serum of Acute Myocardial Infarction patients. The purpose of the study is to compare and correlate the serum levels of High Sensitivity C-Reactive protein and Serum Creatinine Kinase (Total-CK) in Acute Myocardial Infarction. Aim: To Compare and Correlate between the elevation of Serum hs-CRP and the elevation of Serum Creatinine Kinase (Total-CK) in Acute Myocardial infarction (AMI). Materials and Methodology: Serum levels of hs-CRP and Total - CK were measured and compared in blood samples collected within 6-12 hrs after the onset of chest pain in AMI patients. Estimation of serum hs-CRP was done by Immunoturbidimetric assay in Random access analyzer. Estimation of Creatinine Kinase (Total-CK) was done by UV kinetic method in Random access analyzer. Result and Discussion: Serum hs-CRP and Serum Total-CK were estimated in Acute Myocardial Infarction and the results were analyzed. The mean level of hs-CRP in AMI was 8.20mg/L with a standard deviation of +/-2.O9 and the mean level of Total-CK in AMI was1656.52 U/L with a standard deviation of +/ 446.29.The study is statiscally highly significant with a p value of 0.001and it proves hs-CRP to be a definitive diagnostic inflammatory marker of AMI along with other known cardiac enzyme markers like Total-CK. Summary and Conclusion: Present study reveals that hs-CRP levels are higher within 6-12 hrs of onset of chest pain in AMI and hence hs-CRP is a promising novel inflammatory marker of Acute Myocardial Infarction along with other known cardiac enzyme markers like Creatinine Kinase (Total-CK)
Authors and Affiliations
Karpagavel L, N Ananthi, Venkata Ramesh Bonam
Keywords
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